Journal article
Drosophila D1 dopamine receptor mediates caffeine-induced arousal
Proceedings of the National Academy of Sciences - PNAS, Vol.105(51), pp.20392-20397
12/23/2008
DOI: 10.1073/pnas.0806776105
PMCID: PMC2629270
PMID: 19074291
Abstract
The arousing and motor-activating effects of psychostimulants are mediated by multiple systems. In Drosophila, dopaminergic transmission is involved in mediating the arousing effects of methamphetamine, although the neuronal mechanisms of caffeine (CAFF)induced wakefulness remain unexplored. Here, we show that in Drosophila, as in mammals, the wake-promoting effect of CAFF involves both the adenosinergic and dopaminergic systems. By measuring behavioral responses in mutant and transgenic flies exposed to different drug-feeding regimens, we show that CAFFinduced wakefulness requires the Drosophila D1 dopamine receptor (dDA1) in the mushroom bodies. In WT flies, CAFF exposure leads to downregulation of dDA1 expression, whereas the transgenic overexpression of dDA1 leads to CAFF resistance. The wake-promoting effects of methamphetamine require a functional dopamine transporter as well as the dDA1, and they engage brain areas in addition to the mushroom bodies.
Details
- Title: Subtitle
- Drosophila D1 dopamine receptor mediates caffeine-induced arousal
- Creators
- Rozi Andretic - Neurosciences InstituteYoung-Cho Kim - Penn State Univ, Dept Biol, University Pk, PA 16802 USAFrederick S. Jones - Neurosciences InstituteKyung-An Han - Pennsylvania State UniversityRalph J. Greenspan - Neurosciences Institute
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.105(51), pp.20392-20397
- DOI
- 10.1073/pnas.0806776105
- PMID
- 19074291
- PMCID
- PMC2629270
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Number of pages
- 6
- Language
- English
- Date published
- 12/23/2008
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984302212002771
Metrics
6 Record Views