Journal article
Drosophila cacophony Channels: A Major Mediator of Neuronal Ca2+ Currents and a Trigger for K+ Channel Homeostatic Regulation
The Journal of neuroscience, Vol.27(5), pp.1072-1081
01/31/2007
DOI: 10.1523/JNEUROSCI.4746-06.2007
PMID: 17267561
Abstract
The
cacophony
(
cac
) locus in
Drosophila
encodes a Ca
2+
channel α subunit, but little is known about properties of
cac
-mediated currents and functional consequences of
cac
mutations in central neurons. We found that, in
Drosophila
cultured neurons, Ca
2+
currents were mediated predominantly by the
cac
channels. The
cac
channels contribute to low- and high-threshold, fast- and slow-inactivating types of Ca
2+
currents, take part in membrane depolarization, and strongly activate Ca
2+
-activated K
+
current [
I
K(Ca)
]. In
cac
neurons, unexpectedly, voltage-activated transient K
+
current
I
A
is upregulated to a level that matches
I
K(Ca)
reduction, implicating a homeostatic regulation that was mimicked by chronic pharmacological blockade of Ca
2+
currents in wild-type neurons. Among K
+
channel transcripts,
Shaker
mRNA levels were preferentially increased in
cac
flies. However, Ca
2+
current expression levels remained unaltered in several K
+
channel mutants, illustrating a key role of
cac
in developmental regulation of
Drosophila
neuronal excitability.
Details
- Title: Subtitle
- Drosophila cacophony Channels: A Major Mediator of Neuronal Ca2+ Currents and a Trigger for K+ Channel Homeostatic Regulation
- Creators
- I-Feng Peng - Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242Chun-Fang Wu - Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.27(5), pp.1072-1081
- Publisher
- Society for Neuroscience
- DOI
- 10.1523/JNEUROSCI.4746-06.2007
- PMID
- 17267561
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 01/31/2007
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070865602771
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