Journal article
Drug Eluting Versus Bare Metal Stents in Cardiac Allograft Vasculopathy: A Systematic Review of Literature
Catheterization and cardiovascular interventions, Vol.77(7), pp.962-969
06/01/2011
DOI: 10.1002/ccd.22975
PMID: 21413135
Abstract
Background: Cardiac allograft vasculopathy (CAV) is a distinct pathological condition characterized by diffuse and progressive arteriopathy and it is an important determinant of long-term graft survival. Definitive CAV treatment is retransplantation but palliation with stenting might temporarily alleviate it. The benefit of drug eluting stents (DES) over bare metal stents (BMS) in the treatment of such lesions is debatable. We therefore sought to do a literature search to review the available evidence comparing DES to BMS. Methods: We conducted Pub Med, EMBASE, Cochrane database review, Web of Science search of studies comparing DES with BMS in CAV. Available studies were retrospective in nature with either direct comparison groups (n = 5) or historical controls (n = 1). The main outcomes analyzed were in stent restenosis (ISR) during follow-up and clinical outcomes. Results: A total of 312 patients from six studies were included in the review (1995-2007). Most commonly used DES were sirolimus eluting stent. DES appeared to reduce the long-term risk of ISR compared with BMS. Three of the five studies showed a statistically significant reduction in ISR at 12 months while the one study assessing ISR at 6 months showed no significant difference. Clinical endpoints such as death and major adverse cardiac events were not statistically different. Conclusion: DES appear to reduce the incidence of ISR in CAV as compared with BMS. Prospective randomized clinical trials are needed to determine the clinical benefit of DES beyond a reduction in ISR. (C) 2011 Wiley-Liss, Inc.
Details
- Title: Subtitle
- Drug Eluting Versus Bare Metal Stents in Cardiac Allograft Vasculopathy: A Systematic Review of Literature
- Creators
- Tarun W. Dasari - University of Oklahoma Health Sciences CenterThomas A. Hennebry - University of Oklahoma Health Sciences CenterElias B. Hanna - University of Oklahoma Health Sciences CenterJorge F. Saucedo - University of Oklahoma Health Sciences Center
- Resource Type
- Journal article
- Publication Details
- Catheterization and cardiovascular interventions, Vol.77(7), pp.962-969
- Publisher
- Wiley
- DOI
- 10.1002/ccd.22975
- PMID
- 21413135
- ISSN
- 1522-1946
- eISSN
- 1522-726X
- Number of pages
- 8
- Language
- English
- Date published
- 06/01/2011
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359587702771
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