Drug abuse and the simplest neurotransmitter

Collin J Kreple; Yuan Lu; Ryan T LaLumiere; John A Wemmie

doi:10.1021/cn500154w

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Drug abuse and the simplest neurotransmitter

Journal article

Open access

Peer reviewed

Drug abuse and the simplest neurotransmitter

Collin J Kreple, Yuan Lu, Ryan T LaLumiere and John A Wemmie

ACS chemical neuroscience, Vol.5(9), pp.746-748

09/17/2014

DOI: 10.1021/cn500154w

PMCID: PMC4334212

PMID: 25054738

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https://doi.org/10.1021/cn500154wView

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Abstract

Neurotransmitter vesicles are known to concentrate hydrogen ions (or protons), the simplest ion, and to release them during neurotransmission. Furthermore, receptors highly sensitive to protons, acid-sensing ion channels (ASICs), were previously localized on the opposite side of the synaptic cleft on dendritic spines. Now, recent experiments provide some of the strongest support to date that protons function as a neurotransmitter in mice, crossing synapses onto medium spiny neurons of the nucleus accumbens (NAc), activating ASICs, and ultimately suppressing drug abuse-related behaviors.

Protons

Substance-Related Disorders - metabolism

Animals

Synaptic Transmission - physiology

Models, Biological

Humans

Neurotransmitter Agents - pharmacology

Neurotransmitter Agents - metabolism

Substance-Related Disorders - pathology

Synaptic Transmission - drug effects

Mice

Acid Sensing Ion Channels - metabolism

Details

Title: Subtitle: Drug abuse and the simplest neurotransmitter
Creators: Collin J Kreple - Medical Scientist Training Program, ‡Department of Molecular Physiology and Biophysics, §Department of Psychiatry, ∥Interdisciplinary Graduate Program in Neuroscience, ⊥Department of Psychology, and #Department of Neurosurgery, University of Iowa , Iowa City, Iowa 52242, United States
Yuan Lu
Ryan T LaLumiere
John A Wemmie
Resource Type: Journal article
Publication Details: ACS chemical neuroscience, Vol.5(9), pp.746-748
DOI: 10.1021/cn500154w
PMID: 25054738
PMCID: PMC4334212
NLM abbreviation: ACS Chem Neurosci
ISSN: 1948-7193
eISSN: 1948-7193
Publisher: United States
Grant note: T32 NS045549 / NINDS NIH HHS I01 BX000741 / BLRD VA R01 DA034684 / NIDA NIH HHS T32 GM007337 / NIGMS NIH HHS
Language: English
Date published: 09/17/2014
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984003994302771

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