Drug-induced changes in mechanics and structure of cerebral arterioles

G L Baumbach; D D Heistad

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Journal article

Drug-induced changes in mechanics and structure of cerebral arterioles

G L Baumbach and D D Heistad

Journal of hypertension. Supplement, Vol.10(6), pp.S137-S140

08/1992

PMID: 1432316

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Abstract

Cerebral arterioles in stroke-prone spontaneously hypertensive rats (SHRSP) undergo remodeling with a reduction in external diameter, paradoxically becoming more distensible, despite hypertrophy of the vessel wall. Two concepts have been proposed. (1) Remodeling of cerebral arterioles is an important mechanism, in addition to hypertrophy, of encroachment on the vascular lumen in SHRSP. (2) Increases in arteriolar distensibility partly compensate cerebral arterioles for other factors, such as hypertrophy and remodeling, which reduce the dilator capacity of these arterioles in chronic hypertension. Recently, we have studied the effects of reducing blood pressure by drug treatment or carotid clipping on hypertrophy and remodeling of cerebral arterioles in SHRSP. Our findings suggest that (1) pulse pressure may be a more important stimulus than mean pressure for hypertrophy of cerebral blood vessels and (2) remodeling of cerebral arterioles may occur independently of hypertrophy. Treatment that effectively prevents vascular hypertrophy during chronic hypertension may not be effective in preventing remodeling, and may therefore fail to restore cerebral vascular function to normal.

Rats, Inbred SHR

Hydralazine - pharmacology

Rats

Hypertension - drug therapy

Arterioles - drug effects

Hypertension - pathology

Hypertension - physiopathology

Hypertrophy - physiopathology

Arterioles - pathology

Brain - blood supply

Compliance - drug effects

Hydralazine - therapeutic use

Animals

Angiotensin-Converting Enzyme Inhibitors - therapeutic use

Arterioles - physiopathology

Angiotensin-Converting Enzyme Inhibitors - pharmacology

Hemodynamics - drug effects

Chronic Disease

Details

Title: Subtitle: Drug-induced changes in mechanics and structure of cerebral arterioles
Creators: G L Baumbach - Department of Pathology, University of Iowa College of Medicine, Iowa City 52242
D D Heistad
Resource Type: Journal article
Publication Details: Journal of hypertension. Supplement, Vol.10(6), pp.S137-S140
Publisher: England
PMID: 1432316
ISSN: 0952-1178
Grant note: HL-16066 / NHLBI NIH HHS HL-22149 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
Language: English
Date published: 08/1992
Academic Unit: Pathology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040538602771

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