Drug-protein interactions: Mechanisms of potency

Christopher M Cheatum

doi:10.1038/nchem.1586

Back

Drug-protein interactions: Mechanisms of potency

Journal article

Peer reviewed

Drug-protein interactions: Mechanisms of potency

Christopher M Cheatum

Nature chemistry, Vol.5(3), pp.152-153

03/2013

DOI: 10.1038/nchem.1586

PMID: 23422552

View Online

Abstract

Overcoming drug resistance requires drug–protein interactions that persist in spite of mutations, but such interactions are difficult to characterize. Two-dimensional infrared spectroscopy can reveal the dynamics of how key molecular groups interact, allowing new insights into how some drugs overcome resistance.

Nitriles - pharmacology

Rilpivirine

Humans

Nitriles - chemistry

Reverse Transcriptase Inhibitors - pharmacology

HIV-1 - enzymology

Pyrimidines - pharmacology

Pyrimidines - chemistry

Reverse Transcriptase Inhibitors - chemistry

Details

Title: Subtitle: Drug-protein interactions: Mechanisms of potency
Creators: Christopher M Cheatum
Resource Type: Journal article
Publication Details: Nature chemistry, Vol.5(3), pp.152-153
DOI: 10.1038/nchem.1586
PMID: 23422552
NLM abbreviation: Nat Chem
ISSN: 1755-4330
eISSN: 1755-4349
Publisher: England
Language: English
Date published: 03/2013
Academic Unit: Core Research Facilities; Chemistry
Record Identifier: 9983985997702771

Metrics

13 Record Views

10 Times Cited - Web of Science