Journal article
Drug resistance and tolerance in fungi
Nature reviews. Microbiology, Vol.18(6), pp.319-331
06/2020
DOI: 10.1038/s41579-019-0322-2
PMCID: PMC7231573
PMID: 32047294
Abstract
Systemic fungal infections pose a serious clinical problem. Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients do not respond to therapy despite being infected with fungi that are susceptible to the drug. The discordance between overall treatment outcome and low levels of clinical resistance may be attributable to antifungal drug tolerance. In this Review, we define and distinguish resistance and tolerance and discuss the current understanding of the molecular, genetic and physiological mechanisms that contribute to those phenomena. Distinguishing tolerance from resistance might provide important insights into the reasons for treatment failure in some settings.
Details
- Title: Subtitle
- Drug resistance and tolerance in fungi
- Creators
- Judith Berman - Tel Aviv UniversityDamian J Krysan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Microbiology, Vol.18(6), pp.319-331
- DOI
- 10.1038/s41579-019-0322-2
- PMID
- 32047294
- PMCID
- PMC7231573
- NLM abbreviation
- Nat Rev Microbiol
- ISSN
- 1740-1526
- eISSN
- 1740-1534
- Grant note
- R21 AI125094 / NIAID NIH HHS 340087 / European Research Council
- Language
- English
- Date published
- 06/2020
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984297428902771
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