Journal article
Drug therapy reviews: Tricyclic antidepressant and monoamine oxidase inhibitor combination therapy
American journal of health-system pharmacy, Vol.34(9), pp.954-961
09/01/1977
DOI: 10.1093/ajhp/34.9.954
PMID: 333909
Abstract
Combinations of monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) are discussed with regard to general toxicity, drug interactions, animal studies, clinical reports, efficacy of combination therapy and usage conditions. Although MAOI-TCA combinations are usually considered contraindicated, informed opinion has shifted to cautious recommendation for the combination. Only refractory patients in whom less hazardous treatment has failed should be considered for combination therapy. The preferred dosage regimen is administration of the MAOI t.i.d. during the day and the entire TCA dose at bedtime. Patients should be informed of the immediate need for medical advice should side effects occur. It is concluded that the simultaneous administration of these agents is potentially efficacious and safe is carefully monitored and controlled.
Details
- Title: Subtitle
- Drug therapy reviews: Tricyclic antidepressant and monoamine oxidase inhibitor combination therapy
- Creators
- Laura B Ponto - College of Pharmacy, University of Iowa, Iowa City 52242Paul J Perry - College of Pharmacy, University of Iowa, Iowa City 52242Barry I Liskow - College of Medicine, University of Iowa, and Chief of Psychiatry, Iowa City Veterans Administration HospitalHazel H Seaba - Iowa Drug Information Service, College of Pharmacy, University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of health-system pharmacy, Vol.34(9), pp.954-961
- DOI
- 10.1093/ajhp/34.9.954
- PMID
- 333909
- ISSN
- 1079-2082
- eISSN
- 1535-2900
- Language
- English
- Date published
- 09/01/1977
- Academic Unit
- Radiology; Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984051720002771
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