Journal article
Drugs, bugs, and MS: The interplay between disease-modifying therapy and gut microbiota
Neurology: Neuroimmunology and NeuroInflammation, Vol.6(1), e524
2019
DOI: 10.1212/NXI.0000000000000524
PMID: 30569001
Abstract
MS is an inflammatory disease in which both genetic and environmental factors play roles in the predisposition to disease. A number of recent studies suggest that gut microbiota might be a potential environmental factor linked with the pathogenesis of MS. Trillions of bacteria residing in the human gut (gut microbiota) play an important role in maintaining a healthy state, and perturbation of the gut microbiota is associated with exacerbation and/or precipitation of MS. A number of recent studies have shown that patients with MS have gut dysbiosis characterized by altered levels of certain gut bacteria.1–5 Because MS is an inflammatory disease, it is hypothesized that gut bacteria enriched in patients with MS might possess proinflammatory properties, whereas those showing reduced relative abundance might be anti-inflammatory in nature.
Details
- Title: Subtitle
- Drugs, bugs, and MS: The interplay between disease-modifying therapy and gut microbiota
- Creators
- Ashutosh K Mangalam
- Resource Type
- Journal article
- Publication Details
- Neurology: Neuroimmunology and NeuroInflammation, Vol.6(1), e524
- DOI
- 10.1212/NXI.0000000000000524
- PMID
- 30569001
- NLM abbreviation
- Neurol Neuroimmunol Neuroinflamm
- ISSN
- 2332-7812
- eISSN
- 2332-7812
- Language
- English
- Date published
- 2019
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9983905530802771
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