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Drusen Regression after Macula-involving Rhegmatogenous Retinal Detachment Repair
Journal article   Peer reviewed

Drusen Regression after Macula-involving Rhegmatogenous Retinal Detachment Repair

Kyle M Green, Taariq K Mohammed, Jonathan F Russell and Timothy M Boyce
Retinal cases & brief reports, Vol.20(2), pp.252-258
03/2026
DOI: 10.1097/ICB.0000000000001711
PMID: 39752582

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Abstract

To investigate the effect of macula-involving rhegmatogenous retinal detachment (RRD) repair on drusen regression. A retrospective review was performed of patients with drusen who underwent macula-involving RRD repair. Longitudinal optical coherence tomography scans were reviewed by three graders, and each case was grouped into one of three categories: drusen regression, drusen persistence, or mixed. 14 eyes with drusen that underwent macula-involving RRD repair were identified. Surgical repair consisted of pars plana vitrectomy (PPV) in 7 eyes, combined PPV and scleral buckle in 6 eyes, and primary buckle with cryotherapy in 1 eye. Regression of drusen occurred in 6 eyes (43%), persistence of drusen in 5 eyes (36%), and 3 eyes were categorized as mixed (21%). One patient with drusen regression with long-term follow up resulted in geographic atrophy. Although the course of drusen following repair of macula-involving RRDs was highly variable, roughly half of eyes demonstrated marked drusen regression.

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