Journal article
Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
The FASEB Journal, Vol.14(7), pp.835-846
05/2000
DOI: 10.1096/fasebj.14.7.835
PMID: 10783137
Abstract
Age‐related macular degeneration (AMD), a blinding disorder that compromises central vision, is characterized by the accumulation of extracellular deposits, termed drusen, between the retinal pigmented epithelium and the choroid. Recent studies in this laboratory revealed that vitronectin is a major component of drusen. Because vitronectin is also a constituent of abnormal deposits associated with a variety of diseases, drusen from human donor eyes were examined for compositional similarities with other extracellular disease deposits. Thirty‐four antibodies to 29 different proteins or protein complexes were tested for immunoreactivity with hard and soft drusen phenotypes. These analyses provide a partial profile of the molecular composition of drusen. Serum amyloid P component, apolipoprotein E, immunoglobulin light chains, Factor X, and complement proteins (C5 and C5b‐9 complex) were identified in all drusen phenotypes. Transcripts encoding some of these molecules were also found to be synthesized by the retina, retinal pigmented epithelium, and/or choroid. The compositional similarity between drusen and other disease deposits may be significant in view of the recently established correlation between AMD and atherosclerosis. This study suggests that similar pathways may be involved in the etiologies of AMD and other age‐related diseases.—Mullins, R. F., Russell, S. R., Anderson, D. H., Hageman, G. S. Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 14, 835–846 (2000)
Details
- Title: Subtitle
- Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
- Creators
- Robert F Mullins - The University of Iowa Center for Macular DegenerationStephen R Russell - The University of Iowa Center for Macular DegenerationDon H Anderson - Neuroscience Research Institute, University of CaliforniaGregory S Hageman - The University of Iowa Center for Macular Degeneration
- Resource Type
- Journal article
- Publication Details
- The FASEB Journal, Vol.14(7), pp.835-846
- DOI
- 10.1096/fasebj.14.7.835
- PMID
- 10783137
- NLM abbreviation
- FASEB J
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Publisher
- Federation of American Societies for Experimental Biology
- Number of pages
- 12
- Grant note
- NIH (EY06463; EY11515; EY11521; AG00214)
- Language
- English
- Date published
- 05/2000
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983980082602771
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