Dual function of Sox1 in telencephalic progenitor cells

Lixin Kan; Ali Jalali; Li-Ru Zhao; Xiaojing Zhou; Tammy McGuire; Ilias Kazanis; Vasso Episkopou; Alexander G Bassuk; John A Kessler

doi:10.1016/j.ydbio.2007.07.026

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Dual function of Sox1 in telencephalic progenitor cells

Journal article

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Peer reviewed

Dual function of Sox1 in telencephalic progenitor cells

Lixin Kan, Ali Jalali, Li-Ru Zhao, Xiaojing Zhou, Tammy McGuire, Ilias Kazanis, Vasso Episkopou, Alexander G Bassuk and John A Kessler

Developmental biology, Vol.310(1), pp.85-98

2007

DOI: 10.1016/j.ydbio.2007.07.026

PMCID: PMC3437622

PMID: 17719572

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Abstract

The transcription factor, Sox1 has been implicated in the maintenance of neural progenitor cell status, but accumulating evidence suggests that this is only part of its function. This study examined the role of Sox1 expression in proliferation, lineage commitment, and differentiation by telencephalic neural progenitor cells in vitro and in vivo, and further clarified the pattern of Sox1 expression in postnatal and adult mouse brain. Telencephalic neural progenitor cells isolated from Sox1 null embryos formed neurospheres normally, but were specifically deficient in neuronal differentiation. Conversely, overexpression of Sox1 in the embryonic telencephalon in vivo both expanded the progenitor pool and biased neural progenitor cells towards neuronal lineage commitment. Sox1 mRNA and protein were found to be persistently expressed in the postnatal and adult brain in both differentiated and neurogenic regions. Importantly, in differentiated regions Sox1 co-labeled only with neuronal markers. These observations, coupled with previous studies, suggest that Sox1 expression by early embryonic progenitor cells initially helps to maintain the cells in cell cycle, but that continued expression subsequently promotes neuronal lineage commitment.

Neural progenitor cells

Neural stem cells

Sox1

Differentiation

Neurogenesis

Details

Title: Subtitle: Dual function of Sox1 in telencephalic progenitor cells
Creators: Lixin Kan - Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward 10-233, Chicago, IL 60611-3008, USA
Ali Jalali - Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward 10-233, Chicago, IL 60611-3008, USA
Li-Ru Zhao - Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward 10-233, Chicago, IL 60611-3008, USA
Xiaojing Zhou - Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward 10-233, Chicago, IL 60611-3008, USA
Tammy McGuire - Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward 10-233, Chicago, IL 60611-3008, USA
Ilias Kazanis - MRC Clinical Sciences Centre, Imperial College, Du Cane Rd, London W12 0NN, UK
Vasso Episkopou - MRC Clinical Sciences Centre, Imperial College, Du Cane Rd, London W12 0NN, UK
Alexander G Bassuk - Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward 10-233, Chicago, IL 60611-3008, USA
John A Kessler - Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward 10-233, Chicago, IL 60611-3008, USA
Resource Type: Journal article
Publication Details: Developmental biology, Vol.310(1), pp.85-98
DOI: 10.1016/j.ydbio.2007.07.026
PMID: 17719572
PMCID: PMC3437622
NLM abbreviation: Dev Biol
ISSN: 0012-1606
eISSN: 1095-564X
Publisher: Elsevier Inc
Language: English
Date published: 2007
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984020636702771

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