Journal article
Dual isotope brain SPECT imaging for monitoring cognitive activation: physical considerations
Nuclear medicine communications, Vol.14(5), pp.391-396
05/1993
DOI: 10.1097/00006231-199305000-00008
PMID: 8510880
Abstract
The physical considerations of using dual isotope brain SPECT imaging to monitor blood flow changes during cognitive activation studies were investigated. These factors included field uniformity, spatial resolution and crosstalk. Serial dual isotope single photon emission computed tomographic (SPECT) studies of a test tube phantom and an anthropomorphic brain phantom filled with 99Tcm and 123I were made over a 10 h period. The reconstructed counts in the 99Tcm and 123I windows were corrected for crosstalk and were plotted as a function of time. The plotted data from each window decreased over time with a half-life characteristic of each radionuclide. The relative difference between true 123I and 99Tcm region counts has to be of the order of 10% to be statistically significant at the P < 0.05 level.
Details
- Title: Subtitle
- Dual isotope brain SPECT imaging for monitoring cognitive activation: physical considerations
- Creators
- M T Madsen - Department of Radiology, University of Iowa Hospitals and ClinicsD S O'LearyN C AndreasenP T Kirchner
- Resource Type
- Journal article
- Publication Details
- Nuclear medicine communications, Vol.14(5), pp.391-396
- Publisher
- England
- DOI
- 10.1097/00006231-199305000-00008
- PMID
- 8510880
- ISSN
- 0143-3636
- eISSN
- 1473-5628
- Language
- English
- Date published
- 05/1993
- Academic Unit
- Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003963302771
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