Journal article
Dual muscarinic and nicotinic action on a motor program in Drosophila
Journal of neurobiology, Vol.22(4), pp.391-404
06/1991
DOI: 10.1002/neu.480220407
PMID: 1679841
Abstract
The effect of cholinergic agonists and antagonists on the central pattern generator of the pharyngeal muscles has been studied in third instar larvae of Drosophila. The pharyngeal muscles are a group of rhythmically active fibers involved in feeding. Bath application of the cholinergic agonists carbachol, musarine, pilocarpine, and acetylcholine (ACh) to a semiintact preparation including the pharyngeal muscles and the central nervous system (CNS), initiated long-lasting endogenous-like bursting activity in the muscles. The muscarinic antagonists, atropine and scopolamine, blocked these responses as well as endogenous activity. Perfusion with nicotine elicited a short, tonic response that was marginally blocked by mecamylamine but not by curare, α-bungarotoxin, hexamethonium, or the muscarinic antagonists. This is the first time that a response to cholinergic drugs has been examined in Drosophila. The pharyngeal muscle preparation may prove to be a valuable system for studying mutations of cholinergic metabolism, receptors, and second messengers.
Details
- Title: Subtitle
- Dual muscarinic and nicotinic action on a motor program in Drosophila
- Creators
- Michael G GorczycaVivian BudnikKalpana WhiteC. F Wu
- Resource Type
- Journal article
- Publication Details
- Journal of neurobiology, Vol.22(4), pp.391-404
- DOI
- 10.1002/neu.480220407
- PMID
- 1679841
- NLM abbreviation
- J Neurobiol
- ISSN
- 0022-3034
- eISSN
- 1097-4695
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- Number of pages
- 14
- Language
- English
- Date published
- 06/1991
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070820202771
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