Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles

Rebecca K. Chung; Abigail C. Mancuso; Karen M. Summers; Amy E. Sparks; Hakan E. Duran; Rachel B. Mejia

doi:10.1016/j.xfre.2021.05.008

Back

Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles

Journal article

Open access

Peer reviewed

Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles

Rebecca K. Chung, Abigail C. Mancuso, Karen M. Summers, Amy E. Sparks, Hakan E. Duran and Rachel B. Mejia

F&S Reports (Online), Vol.2(3), pp.314-319

09/2021

DOI: 10.1016/j.xfre.2021.05.008

PMCID: PMC8441566

PMID: 34553157

Files and links (1)

url

https://doi.org/10.1016/j.xfre.2021.05.008View

Published (Version of record) Open Access

Abstract

To study the birth rates of normal vs. high responders after dual trigger of final oocyte maturation with gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin in fresh in vitro fertilization (IVF) cycles in which ovarian stimulation was achieved by a flexible GnRH antagonist protocol. Retrospective cohort study. University hospital. In women <35 years of age, 290 fresh IVF cycles using the dual trigger protocol with day 5 embryo transfers from January 2013 to July 2018 were included. Cycles excluded were those with preimplantation genetic testing, gestational carriers, donor oocytes, and fertility preservation. IVF with dual trigger. Clinical pregnancy rate, live birth rate. Comparing normal responders, defined as <30 oocytes retrieved, and high responders, defined as ≥30 oocytes retrieved, the clinical pregnancy rates (67.0% vs. 69.3%, respectively) and live birth rates (60.5% vs. 60.0%, respectively) were not significantly different. No cases of ovarian hyperstimulation syndrome were reported in either group. Ovarian stimulation by a flexible GnRH antagonist protocol followed by dual trigger yields comparable outcomes between normal and high responders in fresh IVF cycles.

Dual trigger

fresh embryo transfer

in vitro fertilization

OHSS

pregnancy outcome

Details

Title: Subtitle: Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles
Creators: Rebecca K. Chung - University Hospitals of Cleveland
Abigail C. Mancuso - University of Iowa
Karen M. Summers - University of Iowa
Amy E. Sparks - University of Iowa
Hakan E. Duran - University of Iowa Hospitals and Clinics
Rachel B. Mejia - University of Iowa
Resource Type: Journal article
Publication Details: F&S Reports (Online), Vol.2(3), pp.314-319
Publisher: Elsevier Inc
DOI: 10.1016/j.xfre.2021.05.008
PMID: 34553157
PMCID: PMC8441566
ISSN: 2666-3341
eISSN: 2666-3341
Language: English
Date published: 09/2021
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9984318222702771

Metrics

31 Record Views