Logo image
Back
Duodenal Mucosal Auto-Transplantation
Journal article   Peer reviewed

Duodenal Mucosal Auto-Transplantation

Kambiz Kadkhodayan, Shayan Irani, Saurabh Chandan, Sagar Pathak, Maham Hayat, Abdullah Abbasi, Muhammad K Hasan, Natalie Cosgrove, Deepanshu Jain, Dennis Yang, …
VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy, Vol.10(10), pp.529-534
10/2025
DOI: 10.1016/j.vgie.2025.05.014
PMCID: PMC12546445
PMID: 41142706

View Online

Abstract

Background and Aims Closure of large defects and post resection strictures can be challenging to manage after endoscopic mucosal resection (EMR) of large duodenal lesions. Duodenal mucosal auto-transplantation (DAT) may offer a new strategy for defect closure and stricture prevention in patients that undergo resection of large lesions in the duodenum. Methods A 57 y/o female underwent piecemeal EMR of a duodenal adenoma involving 60% of the luminal circumference. A mucosal auto-graft (2 x 2 cm) was harvested from adjacent duodenum using standard EMR technique and fixed to the resection bed using helical tacks and hemoclips. This resulted in complete defect closure without luminal compromise. Results On follow up EGD at 6 weeks, we noted graft incorporation, intact helix tacks and clips, and no evidence of duodenal stricture formation. The recipient site showed healthy mucosa, confirmed by biopsy, and the donor site healed well. Histopathology revealed viable duodenal mucosa with submucosal fibrosis. EGD at 6 months revealed well headed donor and recipient sites, without evidence of stricture formation. Conclusions DAT is a feasible technique for closure of large duodenal defects and may reduce stricture risk. Further studies are warranted to evaluate long-term outcomes and broader applicability of this approach.

Details

Metrics

22 Record Views
Logo image