Journal article
Duration of Type I Diabetes Affects Glucagon and Glucose Responses to Insulin-Induced Hypoglycemia
The Western journal of medicine, Vol.141(4), pp.467-471
10/1984
PMCID: PMC1021855
PMID: 6390972
Abstract
The glucagon response to hypoglycemia, which fulfills a primary role toward restoring the plasma glucose level, is blunted or absent in most patients with type I diabetes. To identify predictive factors for this abnormality and for the capability of glycemic counterregulation, we investigated the relationship between the duration of diabetes and glucagon and glucose responses to insulin-induced hypoglycemia. In 18 type I diabetic patients with 1 through 28 years of disease who had no detectable autonomic neuropathy, individual glucagon increments after insulin hypoglycemia were inversely correlated with the duration of disease (r = -.53, P < .025). Patients with disease for ten or fewer years showed a glucagon rise that was lower than in controls but significantly higher than in patients with a duration of more than ten years. The plasma glucose rise after the nadir correlated with peak glucagon increments (r = .60, P < .01); eight of the nine patients with glycemic increments comparable to normals had had diabetes for ten years or less. Thus, having diabetes for more than ten years implied that not only were glucagon responses to insulin hypoglycemia severely compromised but also that the abrupt restoration of plasma glucose levels was impaired. These findings should be taken into account when establishing goals and modalities for tight metabolic control.
Details
- Title: Subtitle
- Duration of Type I Diabetes Affects Glucagon and Glucose Responses to Insulin-Induced Hypoglycemia
- Creators
- Mara LorenziNancy BohannonEva TsalikianJohn H Karam
- Resource Type
- Journal article
- Publication Details
- The Western journal of medicine, Vol.141(4), pp.467-471
- PMID
- 6390972
- PMCID
- PMC1021855
- ISSN
- 0093-0415
- eISSN
- 1476-2978
- Language
- English
- Date published
- 10/1984
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093600402771
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