Journal article
Dynamic Contrast Enhanced MRI for the Evaluation of Lung Perfusion in Idiopathic Pulmonary Fibrosis
The European respiratory journal, Vol.60(4), 2102058
03/10/2022
DOI: 10.1183/13993003.02058-2021
PMCID: PMC10015995
PMID: 35273033
Abstract
The objective of this work was to apply quantitative and semi-quantitative dynamic contrast enhanced MRI (DCE-MRI) methods to evaluate lung perfusion in idiopathic pulmonary fibrosis (IPF).
In this prospective trial 41 subjects, including healthy control (control) and IPF subjects, were studied using DCE-MRI at baseline. IPF subjects were then followed for 1 year, progressive IPF (IPF
) were distinguished from stable IPF (IPF
) subjects based on a decline in percent predicted FVC (FVC%p) or DLCO (DLCO%p) measured during followup visits. 35/41 subjects were retained for final baseline analysis at (control: N=15; IPF
: N=14; IPF
: N=6). Seven measures and their coefficients of variation (CV) were derived using temporally resolved DCE-MRI. Two sets of global and regional comparisons were made: control
IPF groups, and control
IPF
IPF
groups, using linear regression analysis. Each measure was compared to FVC%p, DLCO%p, and the lung clearance index (LCI%p) using a Spearman rank correlation.
DCE-MRI identified regional perfusion differences between control and IPF subjects using first moment transit time (FMTT), contrast uptake slope (SLOPE), and pulmonary blood flow (PBF) (p≤0.05), while global averages did not. FMTT was shorter for IPF
compared to both IPF
(p=0.004) and control groups (p=0.023). Correlations were observed between PBF CV and DLCO%p (r
=-0.48, p=0.022) and %LCI (r
=+0.47, p=0.015). Significant group differences were detected in age (p<0.001), DLCO%p (p<0.001), FVC%p (p=0.001), and LCI%p (p=0.007).
Global analysis obscures regional changes in pulmonary hemodynamics in IPF using DCE-MRI in IPF. Decreased FMTT may be a candidate marker for IPF progression.
Details
- Title: Subtitle
- Dynamic Contrast Enhanced MRI for the Evaluation of Lung Perfusion in Idiopathic Pulmonary Fibrosis
- Creators
- Luis A Torres - University of Wisconsin–MadisonKristine E Lee - University of Wisconsin–MadisonGregory P Barton - University of Wisconsin–MadisonAndrew D Hahn - University of Wisconsin–MadisonNathan Sandbo - University of Wisconsin–MadisonMark L Schiebler - University of Wisconsin–MadisonSean B Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- The European respiratory journal, Vol.60(4), 2102058
- DOI
- 10.1183/13993003.02058-2021
- PMID
- 35273033
- PMCID
- PMC10015995
- NLM abbreviation
- Eur Respir J
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Grant note
- DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: R01 HL126771, R01 HL136965; DOI: 10.13039/100000097, name: National Center for Research Resources, award: S10 OD016394
- Language
- English
- Date published
- 03/10/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering
- Record Identifier
- 9984274951902771
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