Dynamic Functional Connectivity Between Amygdala and Cognitive Control Network Predicts Delay Discounting in Older Adolescents

Attakias T. Mertens; Callum Goldsmith; Derek J. Pavelka; Jacob J. Oleson; Gaelle E. Doucet

doi:10.1002/hbm.70270

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Dynamic Functional Connectivity Between Amygdala and Cognitive Control Network Predicts Delay Discounting in Older Adolescents

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Dynamic Functional Connectivity Between Amygdala and Cognitive Control Network Predicts Delay Discounting in Older Adolescents

Attakias T. Mertens, Callum Goldsmith, Derek J. Pavelka, Jacob J. Oleson and Gaelle E. Doucet

Human brain mapping, Vol.46(10), e70270

07/2025

DOI: 10.1002/hbm.70270

PMCID: PMC12207320

PMID: 40586125

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Abstract

There is a spike in reward sensitivity during adolescence. Delay discounting involves subjective valuation of a reward in context of when it is gained. This study sought to assess if dynamic functional connectivity between the cognitive control network and the amygdala could predict delay discounting in adolescents and young adults. 448 participants were separated into three age groups, including younger and older adolescents and young adults. A sliding‐window approach was used to calculate dynamic functional connectivity between the left/right amygdala and the cognitive control network. Hierarchical models were run for each age group to determine if dynamic functional connectivity could predict delay discounting behavior in two delayed amount conditions above and beyond age and sex. Results showed that dynamic functional connectivity between the left, but not the right, amygdala and cognitive control network significantly predicted delay discounting in the larger amount condition for older adolescents. No significant results were found for the smaller amount condition in older adolescents or either condition in younger adolescents or adults. Stronger dynamic functional connectivity indicated a preference for immediate rewards during a larger amount condition in older adolescents only. This study investigates brain mechanisms behind reward sensitivity in adolescents. Findings indicate that dynamic functional connectivity between the left amygdala and the cognitive control network predicted delay discounting in older adolescents, but not in younger adolescents or adults.

adolescence

amygdala

delay discounting

dynamic functional connectivity

resting-state fMRI

Details

Title: Subtitle: Dynamic Functional Connectivity Between Amygdala and Cognitive Control Network Predicts Delay Discounting in Older Adolescents
Creators: Attakias T. Mertens - Institute for Human Neuroscience
Callum Goldsmith - Institute for Human Neuroscience
Derek J. Pavelka - Institute for Human Neuroscience
Jacob J. Oleson - University of Iowa
Gaelle E. Doucet - Creighton University
Resource Type: Journal article
Publication Details: Human brain mapping, Vol.46(10), e70270
DOI: 10.1002/hbm.70270
PMID: 40586125
PMCID: PMC12207320
NLM abbreviation: Hum Brain Mapp
ISSN: 1065-9471
eISSN: 1097-0193
Publisher: John Wiley & Sons, Inc
Grant note: National Institute of General Medical Sciences: 10.15154/1520708
The HCP-Development 2.0 Release data used in this report came from DOI: 10.15154/1520708. Special thanks to Drs. Vince Calhoun and XiaoSong He for their advice on methodologies and encouragement.
Language: English
Date published: 07/2025
Academic Unit: Biostatistics; Otolaryngology
Record Identifier: 9984843241802771

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