Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles

Feng Chen; Shreya Goel; Reinier Hernandez; Stephen A Graves; Sixiang Shi; Robert J Nickles; Weibo Cai

doi:10.1002/smll.201600194

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Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles

Journal article

Peer reviewed

Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles

Feng Chen, Shreya Goel, Reinier Hernandez, Stephen A Graves, Sixiang Shi, Robert J Nickles and Weibo Cai

Small (Weinheim an der Bergstrasse, Germany), Vol.12(20), pp.2775-2782

05/2016

DOI: 10.1002/smll.201600194

PMCID: PMC4874869

PMID: 27062146

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url

https://www.ncbi.nlm.nih.gov/pmc/articles/4874869View

Open Access

Abstract

Optical imaging has been the primary imaging modality for nearly all of the renal clearable nanoparticles since 2007. Due to the tissue depth penetration limitation, providing accurate organ kinetics non-invasively has long been a huge challenge. Although a more quantitative imaging technique has been developed by labeling nanoparticles with single-photon emission computed tomography (SPECT) isotopes, the low temporal resolution of SPECT still limits its potential for visualizing the rapid dynamic process of renal clearable nanoparticles in vivo. The dynamic positron emission tomography (PET) imaging of renal clearable gold (Au) nanoparticles by labeling them with copper-64 ((64) Cu) to form (64) Cu-NOTA-Au-GSH is reported. Systematic nanoparticle synthesis and characterizations are performed to demonstrate the efficient renal clearance of as-prepared nanoparticles. A rapid renal clearance of (64) Cu-NOTA-Au-GSH is observed (>75%ID at 24 h post-injection) with its elimination half-life calculated to be less than 6 min, over 130 times shorter than previously reported similar nanoparticles. Dynamic PET imaging not only addresses the current challenges in accurately and non-invasively acquiring the organ kinetics, but also potentially provides a highly useful tool for studying renal clearance mechanism of other ultra-small nanoparticles, as well as the diagnosis of kidney diseases in the near future.

Animals

Gold - chemistry

Kidney - metabolism

Kinetics

Metal Nanoparticles - chemistry

Mice

Mice, Inbred BALB C

Positron-Emission Tomography - methods

Tomography, Emission-Computed, Single-Photon

Details

Title: Subtitle: Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles
Creators: Feng Chen - University of Wisconsin–Madison
Shreya Goel - University of Wisconsin–Madison
Reinier Hernandez - University of Wisconsin–Madison
Stephen A Graves - University of Wisconsin–Madison
Sixiang Shi - University of Wisconsin–Madison
Robert J Nickles - University of Wisconsin–Madison
Weibo Cai - University of Wisconsin Carbone Cancer Center
Resource Type: Journal article
Publication Details: Small (Weinheim an der Bergstrasse, Germany), Vol.12(20), pp.2775-2782
DOI: 10.1002/smll.201600194
PMID: 27062146
PMCID: PMC4874869
NLM abbreviation: Small
ISSN: 1613-6810
eISSN: 1613-6829
Grant note: T32 GM008349 / NIGMS NIH HHS T32 CA009206 / NCI NIH HHS R01 CA169365 / NCI NIH HHS P30 CA014520 / NCI NIH HHS
Language: English
Date published: 05/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
Record Identifier: 9984383907802771

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