Journal article
Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice
eLife, Vol.6, e28132
12/15/2017
DOI: 10.7554/elife.28132
PMCID: PMC5760204
PMID: 29243588
Abstract
While research on the cerebellar cortex is crystallizing our understanding of its function in learning behavior, many questions surrounding its downstream targets remain. Here, we evaluate the dynamics of cerebellar interpositus nucleus (IpN) neurons over the course of Pavlovian eyeblink conditioning. A diverse range of learning-induced neuronal responses was observed, including increases and decreases in activity during the generation of conditioned blinks. Trial-by-trial correlational analysis and optogenetic manipulation demonstrate that facilitation in the IpN drives the eyelid movements. Adaptive facilitatory responses are often preceded by acquired transient inhibition of IpN activity that, based on latency and effect, appear to be driven by complex spikes in cerebellar cortical Purkinje cells. Likewise, during reflexive blinks to periocular stimulation, IpN cells show excitation-suppression patterns that suggest a contribution of climbing fibers and their collaterals. These findings highlight the integrative properties of subcortical neurons at the cerebellar output stage mediating conditioned behavior.
Details
- Title: Subtitle
- Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice
- Creators
- Michiel M Ten Brinke - Department of Neuroscience, Erasmus Medical Center, Rotterdam, NetherlandsShane A Heiney - Baylor College of MedicineXiaolu Wang - Erasmus MCMartina Proietti-Onori - Department of Neuroscience, Erasmus Medical Center, Rotterdam, NetherlandsHenk-Jan Boele - Department of Neuroscience, Erasmus Medical Center, Rotterdam, NetherlandsJacob Bakermans - Department of Neuroscience, Erasmus Medical Center, Rotterdam, NetherlandsJavier F Medina - Baylor College of MedicineZhenyu Gao - Erasmus MCChris I De Zeeuw - Netherlands Institute for Neuroscience
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.6, e28132
- DOI
- 10.7554/elife.28132
- PMID
- 29243588
- PMCID
- PMC5760204
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Grant note
- R01 MH093727 / NIMH NIH HHS R21 NS104836 / NINDS NIH HHS R21 AA025572 / NIAAA NIH HHS RF1 MH114269 / NIMH NIH HHS
- Language
- English
- Date published
- 12/15/2017
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984622053302771
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