Journal article
Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts
GeroScience, Vol.47(4), pp.5619-5634
08/2025
DOI: 10.1007/s11357-025-01528-6
PMCID: PMC12397043
PMID: 39888585
Abstract
Brain network dynamics have been extensively explored in patients with subjective cognitive decline (SCD). However, these studies are susceptible to individual differences, scanning parameters, and other confounding factors. Therefore, how to reveal subtle SCD-related subtle changes remains unclear. Cross-sectional and longitudinal resting-state functional magnetic resonance imaging data from both Chinese and Western populations were analyzed. We proposed a framework of dynamic proportional loss of functional connectivity (DPLFC). After its stability was validated, the optimal parameters were applied for the clinical diagnosis of SCD. DPLFC yielded a relatively high intraclass correlation coefficient. In particular, the DPLFC of the left superior frontal gyrus (SFG) progressively decreased along the Alzheimer's disease (AD) continuum. Compared with the traditional index, the DPLFC had better classification performance between cognitively normal controls and patients with SCD. Furthermore, DPLFC was related to Aβ deposition and scale scores. Patients with lower DPLFC values had a greater risk of cognitive decline. Decreased DPLFC in the left SFG may be a potential AD-related neuroimaging biomarker at an early stage.Brain network dynamics have been extensively explored in patients with subjective cognitive decline (SCD). However, these studies are susceptible to individual differences, scanning parameters, and other confounding factors. Therefore, how to reveal subtle SCD-related subtle changes remains unclear. Cross-sectional and longitudinal resting-state functional magnetic resonance imaging data from both Chinese and Western populations were analyzed. We proposed a framework of dynamic proportional loss of functional connectivity (DPLFC). After its stability was validated, the optimal parameters were applied for the clinical diagnosis of SCD. DPLFC yielded a relatively high intraclass correlation coefficient. In particular, the DPLFC of the left superior frontal gyrus (SFG) progressively decreased along the Alzheimer's disease (AD) continuum. Compared with the traditional index, the DPLFC had better classification performance between cognitively normal controls and patients with SCD. Furthermore, DPLFC was related to Aβ deposition and scale scores. Patients with lower DPLFC values had a greater risk of cognitive decline. Decreased DPLFC in the left SFG may be a potential AD-related neuroimaging biomarker at an early stage.
Details
- Title: Subtitle
- Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts
- Creators
- Luyao WangSusan K SchultzHyungsub ShimWenjing Hu - Shanghai UniversityFan Dong - Shanghai UniversityCan Sheng - Affiliated Hospital of Jining Medical UniversityJinglong Wu - Shanghai UniversityYing Han - Hainan UniversityJiehui Jiang - Shanghai UniversityMichael W WeinerPaul AisenRonald PetersenClifford R JackWilliam JagustJohn Q TrojanowskiArthur W TogaLaurel BeckettRobert C GreenAndrew J SaykinLeslie M ShawJohn MorrisZaven KhachaturianGreg SorensenLew KullerMarcus RaichleSteven PaulPeter DaviesHoward FillitFranz HeftiDavid HoltzmanMarek M MesulamWilliam PotterPeter SnyderAdam SchwartzTom MontineRonald G ThomasMichael DonohueSarah WalterDevon GessertTamie SatherGus JiminezDanielle HarveyMatthew BernsteinPaul ThompsonNorbert SchuffBret BorowskiJeff GunterMatt SenjemPrashanthi VemuriDavid Jones - Mayo ClinicKejal KantarciChad WardRobert A KoeppeNorm FosterEric M ReimanKewei ChenChet MathisSusan LandauNigel J CairnsErin HouseholderLisa Taylor-ReinwaldVirginia LeeMagdalena KoreckaMichal FigurskiKaren CrawfordScott NeuTatiana M oudSteven G PotkinLi ShenKelley FaberSungeun KimKwangsik NhoLeon ThalNeil BuckholtzMarylyn AlbertRichard FrankJohn HsiaoJeffrey KayeJoseph QuinnBetty LindRaina CarterSara DolenLon S SchneiderSonia PawluczykMauricio BecceraLiberty TeodoroBryan M SpannJames BrewerHelen VanderswagAdam FleisherJudith L HeidebrinkJoanne L LordSara S MasonColleen S AlbersDavid KnopmanKris JohnsonRachelle S DoodyJavier Villanueva-MeyerMunir ChowdhurySusan RountreeMimi DangYaakov SternLawrence S HonigKaren L BellBeau AncesMaria CarrollSue LeonMark A MintunStacy SchneiderAngela OliverDaniel MarsonRandall GriffithDavid ClarkDavid GeldmacherJohn BrockingtonErik RobersonHillel GrossmanEffie MitsisLeyla de Toledo-MorrellRaj C ShahRanjan DuaraDaniel VaronMaria T GreigPeggy RobertsChiadi OnyikeDaniel D'AgostinoStephanie KielbJames E GalvinBrittany CerboneChristina A MichelHenry RusinekMony J de LeonLidia GlodzikSusan De SantiPMurali DoraiswamyJeffrey R PetrellaTerence Z WongSteven E ArnoldJason H KarlawishDavid WolkCharles D SmithGreg JichaPeter HardyPartha SinhaElizabeth OatesGary ConradOscar L LopezMaryAnn OakleyDonna M SimpsonAnton P PorsteinssonBonnie S GoldsteinKim MartinKelly M MakinoMSaleem IsmailConnie BrandRuth A MulnardGaby ThaiCatherine McAdams-OrtizKyle WomackDana MathewsMary QuicenoRamon Diaz-ArrastiaRichard KingMyron WeinerKristen Martin-CookMichael DeVousAllan I LeveyJames J LahJanet S CellarJeffrey M BurnsHeather S AndersonRussell H SwerdlowLiana ApostolovaKathleen TingusEllen WooDaniel H S SilvermanPo H LuGeorge BartzokisNeill R Graff-RadfordFrancine ParfittTracy KendallHeather JohnsonMartin R FarlowAnn Marie HakeBrandy R MatthewsScott HerringCynthia HuntChristopher H van DyckRichard E CarsonMartha G MacAvoyHoward ChertkowHoward BergmanChris HoseinGing-Yuek Robin HsiungHoward FeldmanBenita MudgeMichele AssalyCharles BernickDonna MunicAndrew KerteszJohn RogersDick TrostDiana KerwinKristine LipowskiChuang-Kuo WuNancy JohnsonCarl SadowskyWalter MartinezTeresa VillenaRaymond Scott TurnerKathleen JohnsonBrigid ReynoldsReisa A SperlingKeith A JohnsonGad MarshallMeghan FreyBarton LaneAllyson RosenJared TinklenbergMarwan N SabbaghChristine M BeldenSandra A JacobsonSherye A SirrelNeil KowallRonald KillianyAndrew E BudsonAlexander NorbashPatricia Lynn JohnsonJoanne AllardAlan LernerPaula OgrockiLeon HudsonEvan FletcherOwen CarmichaeJohn OlichneyCharles DeCarliSmita KitturMichael BorrieT-Y LeeRob BarthaSterling JohnsonSanjay AsthanaCynthia M CarlssonAdrian PredaDana NguyenPierre TariotStephanie ReederVernice BatesHoracio CapoteMichelle RainkaDouglas W ScharreMaria KatakiAnahita AdeliEarl A ZimmermanDzintra CelminsAlice D BrownGodfrey D PearlsonKaren BlankKaren AndersonRobert B SantulliTamar J KitzmillerEben S SchwartzKaycee M SinkJeff D WilliamsonPradeep GargFranklin WatkinsBrian R OttHenry QuerfurthGeoffrey TremontStephen SallowayPaul MalloyStephen CorreiaHoward J RosenBruce L MillerJacobo MintzerKenneth SpicerDavid BachmanStephen PasternakIrina RachinskyDick DrostNunzio PomaraRaymundo HernandoAntero SarraelLaura L Boles PontoKaren Elizabeth SmithNorman RelkinGloria ChaingLisa RaudinAmanda SmithKristin FargherBalebail Ashok RajThomas NeylanJordan GrafmanMelissa DavisRosemary MorrisonJacqueline HayesShannon FinleyKarl FriedlDebra FleischmanKonstantinos ArfanakisOlga JamesDino MassogliaJJay FruehlingSandra HardingElaine R PeskindEric C PetrieGail LiJerome A YesavageJoy L TaylorAnsgar J FurstAlzheimer’s Disease Neuroimaging Initiative
- Resource Type
- Journal article
- Publication Details
- GeroScience, Vol.47(4), pp.5619-5634
- DOI
- 10.1007/s11357-025-01528-6
- PMID
- 39888585
- PMCID
- PMC12397043
- NLM abbreviation
- Geroscience
- ISSN
- 2509-2723
- eISSN
- 2509-2723
- Publisher
- SPRINGER
- Grant note
- National Natural Science Foundation of ChinaShanghai Science and Technology Development FundsScience and Technology InnovationScience and Technology Innovation
The authors would like to thank all the participants and the families of them. The authors also would like to thank the National Natural Science Foundation of China, Shanghai Science and Technology Development Funds, and Science and Technology Innovation for the support of the study.
- Language
- English
- Electronic publication date
- 01/31/2025
- Date published
- 08/2025
- Academic Unit
- Neurology; Radiology; Psychiatry
- Record Identifier
- 9984781370502771
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