Journal article
Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
Cells (Basel, Switzerland), Vol.11(16), p.2557
08/01/2022
DOI: 10.3390/cells11162557
PMCID: PMC9406725
PMID: 36010634
Abstract
Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a "molecular scissor" to form endocytic vesicles and is a critical regulator among the proteins involved in endocytosis. Some GTPases (e.g., Cdc42, arf6, RhoA), membrane proteins (e.g., flotillins, tetraspanins), and secondary messengers (e.g., calcium) mediate dynamin-independent endocytosis. These pathways may be convergent, as multiple pathways exist in a single cell. However, what determines the specific path of endocytosis is complex and challenging to comprehend. This review summarizes the mechanisms of dynamin-independent endocytosis, the involvement of microRNAs, and factors that contribute to the cellular decision about the specific route of endocytosis.
Details
- Title: Subtitle
- Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
- Creators
- Chayanika Gundu - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, Telangana, IndiaVijay Kumar Arruri - Univ Wisconsin, Dept Neurol Surg, Madison, WI 53792 USAPoonam Yadav - University of the PunjabUmashanker Navik - University of the PunjabAshutosh Kumar - Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmacol & Toxicol, Kolkata 700054, W Bengal, IndiaVeda Sudhir Amalkar - Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USAAjit Vikram - University of IowaRavinder Reddy Gaddam - Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Cells (Basel, Switzerland), Vol.11(16), p.2557
- DOI
- 10.3390/cells11162557
- PMID
- 36010634
- PMCID
- PMC9406725
- NLM abbreviation
- Cells
- ISSN
- 2073-4409
- eISSN
- 2073-4409
- Publisher
- Mdpi
- Number of pages
- 16
- Grant note
- N0001142012147 / DOD; United States Department of Defense I01 BX002940 / VA Merit Award; US Department of Veterans Affairs 828081 / American Heart Association (AHA); American Heart Association 18CDA34080125 / AHA; American Heart Association
- Language
- English
- Date published
- 08/01/2022
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984359852702771
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