Dysferlin and muscle membrane repair

Renzhi Han; Kevin P Campbell

doi:10.1016/j.ceb.2007.07.001

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Journal article

Peer reviewed

Dysferlin and muscle membrane repair

Renzhi Han and Kevin P Campbell

Current opinion in cell biology, Vol.19(4), pp.409-416

08/2007

DOI: 10.1016/j.ceb.2007.07.001

PMCID: PMC2144911

PMID: 17662592

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Abstract

The ability to repair membrane damage is conserved across eukaryotic cells and is necessary for the cells to survive a variety of physiological and pathological membrane disruptions. Membrane repair is mediated by rapid Ca(2+)-triggered exocytosis of various intracellular vesicles, such as lysosomes and enlargeosomes, which lead to the formation of a membrane patch that reseals the membrane lesion. Recent findings suggest a crucial role for dysferlin in this repair process in muscle, possibly as a Ca(2+) sensor that triggers vesicle fusion. The importance of membrane repair is highlighted by the genetic disease, dysferlinopathy, in which the primary defect is the loss of Ca(2+)-regulated membrane repair due to dysferlin deficiency. Future research on dysferlin and its interacting partners will enhance the understanding of this important process and provide novel avenues to potential therapies.

Animals

Calcium - physiology

Models, Biological

Protein-Tyrosine Kinases - metabolism

Humans

Dysferlin

Cell Membrane - metabolism

Membrane Proteins - metabolism

Muscle, Skeletal - physiology

Muscle, Skeletal - cytology

Regeneration - physiology

Muscle Fibers, Skeletal - physiology

Details

Title: Subtitle: Dysferlin and muscle membrane repair
Creators: Renzhi Han - Howard Hughes Medical Institute, Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Kevin P Campbell
Resource Type: Journal article
Publication Details: Current opinion in cell biology, Vol.19(4), pp.409-416
DOI: 10.1016/j.ceb.2007.07.001
PMID: 17662592
PMCID: PMC2144911
NLM abbreviation: Curr Opin Cell Biol
ISSN: 0955-0674
eISSN: 1879-0410
Publisher: England
Grant note: R01 AR051199-04 / NIAMS NIH HHS\nU54 NS053672-03 / NINDS NIH HHS\nU54 NS053672 / NINDS NIH HHS\n1 U54 NS053672 / NINDS NIH HHS\nR01 AR051199 / NIAMS NIH HHS
Language: English
Date published: 08/2007
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
Record Identifier: 9984068372602771

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