Journal article
Dysfunctional cortico-cerebellar circuits cause ‘cognitive dysmetria’ in schizophrenia
Neuroreport, Vol.9(8), pp.1895-1899
06/01/1998
DOI: 10.1097/00001756-199806010-00042
PMID: 9665622
Abstract
WE examined regional cerebral blood flow (rCBF) during a long-term recognition memory task for words in schizophrenic patients and in healthy subjects using positron emission tomography (PET). The task was designed so that performance scores were similar in the patient and control subjects. This memory retrieval task did not increase rCBF in the patientsʼ prefrontal cortex, precuneus and cerebellum as much as it did in the control group. These results point to a dysfunctional corticocerebellar circuit leading to poorly coordinated mental activity (‘cognitive dysmetria’), which could explain the broad range of schizophrenic symptoms. In addition, other brain areas were more activated by the task in the patient group than in the control group and may form a compensatory network performing the memory retrieval task by assisting or replacing the dysfunctional cortico-cerebellar circuit.
Details
- Title: Subtitle
- Dysfunctional cortico-cerebellar circuits cause ‘cognitive dysmetria’ in schizophrenia
- Creators
- Anne Wiser - 1Mental Health Clinical Research Center, University of Iowa, College of Medicine, 2911 JPP, 200 Hawkins Drive, Iowa City, IA 52242-1057, USANancy AndreasenDaniel OʼLearyG WatkinsLaura Boles PontoRichard Hichwa
- Resource Type
- Journal article
- Publication Details
- Neuroreport, Vol.9(8), pp.1895-1899
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00001756-199806010-00042
- PMID
- 9665622
- ISSN
- 0959-4965
- eISSN
- 1473-558X
- Language
- English
- Date published
- 06/01/1998
- Academic Unit
- Radiology; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984003960702771
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