Journal article
Dysphagia, Stricture, and Pneumonia in Head and Neck Cancer Patients: Does Treatment Modality Matter?
Annals of otology, rhinology & laryngology, Vol.119(6), pp.391-397
06/01/2010
DOI: 10.1177/000348941011900605
PMID: 20583737
Abstract
Objectives: Dysphagia-related sequelae are common after head and neck cancer treatment. Our aims were 1) to document overall and site-specific dysphagia, stricture, and pneumonia rates in a Medicare population, 2) to calculate treatment-specific rates and adjusted odds of developing these complications, and 3) to track changes in rates between 1992 and 1999.
Methods: Head and neck cancer patients between 1992 and 1999 were identified in combined Surveillance Epidemiology and End Results (SEER) registry and Medicare databases. Multivariate analyses determined odds of dysphagia, stricture, and pneumonia based on modality.
Results: Of 8,002 patients, 40% of experienced dysphagia, 7% stricture, and 10% pneumonia within 3 years of treatment. In adjusted analyses, patients treated with chemoradiation had more than 2.5-times-greater odds of dysphagia than did those treated with surgery alone. Combined therapy was associated with increased odds of stricture (p < 0.05). The odds of pneumonia were increased in patients treated with radiation with or without chemotherapy. Temporally, the dysphagia rates increased 10% during this period (p < 0.05).
Conclusions: Sequelae of head and neck cancer treatment are common and differ by treatment regimen. Those treated with chemoradiation had higher odds of experiencing dysphagia and pneumonia, whereas patients treated with any combined therapy more commonly experienced stricture. These sequelae represent major sources of morbidity and mortality in this population.
Details
- Title: Subtitle
- Dysphagia, Stricture, and Pneumonia in Head and Neck Cancer Patients: Does Treatment Modality Matter?
- Creators
- David O. Francis - University of WashingtonErnest A. Weymuller - University of WashingtonUpendra Parvathaneni - University of WashingtonAlbert L. Merati - University of WashingtonBevan Yueh - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Annals of otology, rhinology & laryngology, Vol.119(6), pp.391-397
- DOI
- 10.1177/000348941011900605
- PMID
- 20583737
- NLM abbreviation
- Ann Otol Rhinol Laryngol
- ISSN
- 0003-4894
- eISSN
- 1943-3572
- Publisher
- ANNALS PUBL CO
- Number of pages
- 7
- Grant note
- American Academy of Otolaryngology Head and Neck Surgery Foundation Health Service Research CORE
- Language
- English
- Date published
- 06/01/2010
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984966750202771
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