Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton

Michael D Henry; Kevin P Campbell

doi:10.1016/S0955-0674(96)80103-7

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Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton

Journal article

Peer reviewed

Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton

Michael D Henry and Kevin P Campbell

Current opinion in cell biology, Vol.8(5), pp.625-631

1996

DOI: 10.1016/S0955-0674(96)80103-7

PMID: 8939660

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Abstract

Dystroglycan provides a crucial linkage between the cytoskeleton and the basement membrane for skeletal muscle cells. Disruption of this linkage leads to various forms of muscular dystrophy. Significant recent advances in understanding the structure and function of dystroglycan include detailed in vitro and in vivo analyses of its binding partners in muscle, an examination of its function at the neuromuscular junction, and emerging evidence of its roles in nonmuscle tissues.

MuSK muscle-specific kinase

DGC dystrophin—glycoprotein complex

MASC myotube-associated specificity component

AChR acetylcholine receptor

ECM extracellular matrix

GAG glycosaminoglycan

NMJ neuromuscular junction

Details

Title: Subtitle: Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton
Creators: Michael D Henry
Kevin P Campbell
Resource Type: Journal article
Publication Details: Current opinion in cell biology, Vol.8(5), pp.625-631
DOI: 10.1016/S0955-0674(96)80103-7
PMID: 8939660
NLM abbreviation: Curr Opin Cell Biol
ISSN: 0955-0674
eISSN: 1879-0410
Publisher: Elsevier Ltd
Language: English
Date published: 1996
Academic Unit: Neurology; Molecular Physiology and Biophysics; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Urology
Record Identifier: 9984020734802771

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