Journal article
Dystroglycan in development and disease
Current opinion in cell biology, Vol.10(5), pp.594-601
1998
DOI: 10.1016/S0955-0674(98)80034-3
PMID: 9818169
Abstract
Our understanding of the structure and function of dystroglycan, a cell surface laminin/agrin receptor, has increased dramatically over the past two years. Structural studies, analysis of its binding partners, and targeted gene disruption have all contributed to the elucidation of the biological role of dystroglycan in development and disease. It is now apparent that dystroglycan plays a critical role in the pathogenesis of several muscular dystrophies and serves as a receptor for a human pathogen as well as being involved in early development, organ morphogenesis, and synaptogenesis.
Details
- Title: Subtitle
- Dystroglycan in development and disease
- Creators
- Madeleine DurbeejMichael D HenryKevin P Campbell
- Resource Type
- Journal article
- Publication Details
- Current opinion in cell biology, Vol.10(5), pp.594-601
- DOI
- 10.1016/S0955-0674(98)80034-3
- PMID
- 9818169
- NLM abbreviation
- Curr Opin Cell Biol
- ISSN
- 0955-0674
- eISSN
- 1879-0410
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 1998
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Urology; Internal Medicine
- Record Identifier
- 9984068375802771
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