Journal article
Dystroglycan is a binding protein of laminin and merosin in peripheral nerve
FEBS letters, Vol.352(1), pp.49-53
1994
DOI: 10.1016/0014-5793(94)00917-1
PMID: 7925941
Abstract
α-Dystroglycan, a 156 kDa dystrophin-associated glycoprotein, binds laminin in skeletal muscle. Here we demonstrate that α-dystroglycan is a binding protein of laminin (A/B1/B2) and merosin (M/B1/B2) in peripheral nerve. Immunocytochemical analysis demonstrates the localization of α-dystroglycan and merosin surrounding myelin sheath of peripheral nerve fibers. Biochemical analysis demonstrates that the 120 kDa peripheral nerve α-dystroglycan binds merosin as well as laminin. The binding of laminin and merosin is Ca
2+ dependent and is inhibited by NACl and heparin. Recently, merosin was shown to be deficient in the peripheral nerve of
dy mice which have defects in myelination. The interaction between α-dystroglycan and merosin may play a role in the regulation of Schwann cell myelination and/or maintenance of myelin sheath.
Details
- Title: Subtitle
- Dystroglycan is a binding protein of laminin and merosin in peripheral nerve
- Creators
- Hiroki Yamada - Department of Neurology and Neuroscience, Teikyo University School of Medicine 2-11-1 Kaga, Itabashi-ku, Tokyo 173, JapanTeruo Shimizu - Department of Neurology and Neuroscience, Teikyo University School of Medicine 2-11-1 Kaga, Itabashi-ku, Tokyo 173, JapanTakeshi Tanaka - Saitama Red Cross Blood Center, 903 Kamiochiai, Yono 338, JapanKevin P Campbell - Howard Hughes Medical Institute and Department of Physiology & Biophysics, University of Iowa College of Medicine, 400 EMRB, Iowa City, IA 52242, USAKiichiro Matsumura - Department of Neurology and Neuroscience, Teikyo University School of Medicine 2-11-1 Kaga, Itabashi-ku, Tokyo 173, Japan
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.352(1), pp.49-53
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0014-5793(94)00917-1
- PMID
- 7925941
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Language
- English
- Date published
- 1994
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984068388002771
Metrics
9 Record Views