Journal article
Dystrophin constitutes 5% of membrane cytoskeleton in skeletal muscle
FEBS letters, Vol.283(2), pp.230-234
06/03/1991
DOI: 10.1016/0014-5793(91)80595-T
PMID: 2044761
Abstract
Dystrophin, which is absent in skeletal muscle of Duchenne muscular dystrophy patients, has not been considered to play a major structural role in the cell membrane of skeletal muscle because of its low abundance (∼ 0.002% of total muscle protein). Here, were have determined the relative abundance of dystrophin in a membrane cytoskeleton preparation and found that dystrophin constitutes approximately 5% of the total membrane cytoskeleton fraction of skeletal muscle sarcolemma. In addition, dystrophin can be removed from surcolemma by alkaline treatment. Thus, our results have demonstrated that dystrophin is a major component of the subsurcolemmal cytoskeleton in skeletal muscle and suggest that dystrophin could play a major structural role in the cell membrane of skeletal muscle.
Details
- Title: Subtitle
- Dystrophin constitutes 5% of membrane cytoskeleton in skeletal muscle
- Creators
- Kay OhlendieckKevin P Campbell
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.283(2), pp.230-234
- DOI
- 10.1016/0014-5793(91)80595-T
- PMID
- 2044761
- NLM abbreviation
- FEBS Lett
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 06/03/1991
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984020862102771
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