Journal article
Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle
Neuron (Cambridge, Mass.), Vol.7(3), pp.499-508
1991
DOI: 10.1016/0896-6273(91)90301-F
PMID: 1654951
Abstract
Dystrophin-related protein (DRP) is an autosomal gene product with high homology to dystrophin. We have used highly specific antibodies to the unique C-terminal peptide sequences of DRP and dystrophin to examine the subcellular localization and biochemical properties of DRP in adult skeletal muscle. DRP is enriched in isolated sarcolemma from control and mdx mouse muscle, but is much less abundant than dystrophin. Immunofluorescence microscopy localized DRP almost exclusively to the neuromuscular junction region in rabbit and mouse skeletal muscle, as well as mdx mouse muscle and denervated mouse muscle. DRP is also present in normal size and abundance and localizes to the neuromuscular junction region in muscle from the dystrophic mouse model
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. Thus, DRP is a junction-specific membrane cytoskeletal protein that may play an important role in the organization of the postsynaptic membrane of the neuromuscular junction.
Details
- Title: Subtitle
- Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle
- Creators
- Kay OhlendieckJames M ErvastiKiichiro MatsumuraSteven D KahlCynthia J LeveilleKevin P Campbell
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.7(3), pp.499-508
- DOI
- 10.1016/0896-6273(91)90301-F
- PMID
- 1654951
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1991
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984020740702771
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