Journal article
Dystrophin–glycoprotein complex: Its role in the molecular pathogenesis of muscular dystrophies
Muscle & nerve, Vol.17(1), pp.2-15
01/1994
DOI: 10.1002/mus.880170103
PMID: 8264699
Abstract
Dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene, is associated with a large oligomeric complex of sarcolemmal glycoproteins, including dystroglycan which provides a linkage to the extracellular matrix component, laminin. In patients with DMD, the absence of dystrophin leads to the loss in all of the dystrophin‐associated proteins, causing the disruption of the linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. This may render the sarcolemma vulnerable to physical stress. These recent developments in the research concerning the function of the dystrophin–glycoprotein complex pave a way for the better understanding of the pathogenesis of muscular dystrophies. © 1994 John Wiley & Sons, Inc.
Details
- Title: Subtitle
- Dystrophin–glycoprotein complex: Its role in the molecular pathogenesis of muscular dystrophies
- Creators
- Kiichiro MatsumuraKevin P Campbell
- Resource Type
- Journal article
- Publication Details
- Muscle & nerve, Vol.17(1), pp.2-15
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- DOI
- 10.1002/mus.880170103
- PMID
- 8264699
- ISSN
- 0148-639X
- eISSN
- 1097-4598
- Number of pages
- 14
- Language
- English
- Date published
- 01/1994
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984068264502771
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