Journal article
E-Cadherin: A conductor of cellular signaling
Current opinion in cell biology, Vol.95, 102559
08/2025
DOI: 10.1016/j.ceb.2025.102559
PMCID: PMC12340774
PMID: 40513205
Abstract
Upon engagement of E-cadherin or when mechanical force is applied, E-cadherin recruits cytoskeletal proteins and triggers various signal transduction cascades including PI3K, Src, Rho family GTPases, kinases, YAP/TAZ, AMPK, and other metabolic enzymes. These cascades modulate E-cadherin's stability, viscosity, and its connection to the actin cytoskeleton, thereby reinforcing cell-cell adhesion.
Details
- Title: Subtitle
- E-Cadherin: A conductor of cellular signaling
- Creators
- Rachel J Kehrberg - University of IowaKris A DeMali - Roy J. and Lucille A. Carver College of Medicine at the University of Iowa, Department of Biochemistry and Molecular Biology, 51 Newton Rd, Iowa City, IA 52242, USA. Electronic address: kris-demali@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Current opinion in cell biology, Vol.95, 102559
- DOI
- 10.1016/j.ceb.2025.102559
- PMID
- 40513205
- PMCID
- PMC12340774
- NLM abbreviation
- Curr Opin Cell Biol
- ISSN
- 1879-0410
- eISSN
- 1879-0410
- Publisher
- CURRENT BIOLOGY LTD
- Grant note
- National Institutes of Health: R35GM136291
This work was supported by National Institutes of Health grant #R35GM136291 to KAD. All figures were created with BioRender.com .
- Language
- English
- Electronic publication date
- 06/12/2025
- Date published
- 08/2025
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
- Record Identifier
- 9984831602302771
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