E-Cigarette, or Vaping, Product Use Associated Lung Injury (EVALI) with Acute Respiratory Failure in Three Adolescent Patients: a Clinical Timeline, Treatment, and Product Analysis

Ramya Billa; Cody Tigges; Niranjan Vijayakumar; Joshua Radke; Caitlin Pedati; Rebecca Weiner; Daniel McCabe

doi:10.1007/s13181-020-00765-9

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E-Cigarette, or Vaping, Product Use Associated Lung Injury (EVALI) with Acute Respiratory Failure in Three Adolescent Patients: a Clinical Timeline, Treatment, and Product Analysis

Journal article

Open access

Peer reviewed

E-Cigarette, or Vaping, Product Use Associated Lung Injury (EVALI) with Acute Respiratory Failure in Three Adolescent Patients: a Clinical Timeline, Treatment, and Product Analysis

Ramya Billa, Cody Tigges, Niranjan Vijayakumar, Joshua Radke, Caitlin Pedati, Rebecca Weiner and Daniel McCabe

Journal of medical toxicology, Vol.16(3), pp.248-254

07/01/2020

DOI: 10.1007/s13181-020-00765-9

PMCID: PMC7095090

PMID: 32193828

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Abstract

Introduction E-cigarette, or vaping, product use associated lung injury (EVALI) has become a recent concern among public health officials. Factors that contribute to the concern include an increasing number of cases over time, the severity of the illness, and an unknown understanding of the pathophysiology and etiology of the illness. Case Series We cared for three adolescent patients with acute respiratory failure secondary to EVALI. All three patients were treated with high-dose steroids in addition to antimicrobials, which resulted in clinical improvement and resolution of their respiratory failure. Pulmonary function testing was performed on these previously healthy patients both acutely and subacutely. Additionally, we report the results from the laboratory analysis of one vaping device fluid which revealed previously unpublished components within these products. Discussion EVALI is a recent public health concern without a known etiology which can cause life-threatening lung injury in patients without prior lung pathology. We hope these cases will highlight the importance of return precautions in adolescents with vague respiratory symptoms and provide a cautionary tale to providers while they counsel patients regarding the use of these products.

Life Sciences & Biomedicine

Science & Technology

Toxicology

Details

Title: Subtitle: E-Cigarette, or Vaping, Product Use Associated Lung Injury (EVALI) with Acute Respiratory Failure in Three Adolescent Patients: a Clinical Timeline, Treatment, and Product Analysis
Creators: Ramya Billa - University of Iowa
Cody Tigges - University of Iowa
Niranjan Vijayakumar - University of Iowa
Joshua Radke - University of Iowa
Caitlin Pedati - Iowa Department of Public Health
Rebecca Weiner - University of Iowa
Daniel McCabe - University of Iowa
Resource Type: Journal article
Publication Details: Journal of medical toxicology, Vol.16(3), pp.248-254
DOI: 10.1007/s13181-020-00765-9
PMID: 32193828
PMCID: PMC7095090
NLM abbreviation: J Med Toxicol
ISSN: 1556-9039
eISSN: 1937-6995
Publisher: Springer Nature
Number of pages: 7
Language: English
Date published: 07/01/2020
Academic Unit: Critical Care; Pulmonary Medicine; Stead Family Department of Pediatrics; Emergency Medicine
Record Identifier: 9984297150802771

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