E17 Diffusion Weighted Imaging Study Of Prefrontal Cortex White Matter In Prodromal Huntington Disease

R Kim; J Matsui; D Wassermann; J Vaidya; H Johnson; V Magnotta; J D Long; J A Mills; M Lowe; K Sakaie; S Rao; M Smith; J Paulsen

doi:10.1136/jnnp-2014-309032.120

Back

E17 Diffusion Weighted Imaging Study Of Prefrontal Cortex White Matter In Prodromal Huntington Disease

Journal article

Open access

Peer reviewed

E17 Diffusion Weighted Imaging Study Of Prefrontal Cortex White Matter In Prodromal Huntington Disease

R Kim, J Matsui, D Wassermann, J Vaidya, H Johnson, V Magnotta, J D Long, J A Mills, M Lowe, K Sakaie, …

Journal of neurology, neurosurgery and psychiatry, Vol.85(Suppl 1), pp.A42-A42

09/01/2014

DOI: 10.1136/jnnp-2014-309032.120

Files and links (1)

url

https://doi.org/10.1136/jnnp-2014-309032.120View

Published (Version of record) Open Access

Abstract

BackgroundThere is considerable interest in finding reliable indicators of Huntington's disease (HD) progression to judge the efficacy of novel treatments that slow or stop disease onset before debilitating signs appear. Diffusion-weighted imaging (DWI) may provide a reliable marker of disease progression by characterising diffusivity changes in white matter (WM) in individuals with prodromal HD. The prefrontal cortex (PFC) may play a role in HD progression due to its prominent striatal connexions and documented role in executive function.AimsThe primary goal is to assess alterations in the white matter tracts of HD gene-positive individuals using DWI and examine its association with motor, cognitive, psychiatric, demographic and genetic variables.MethodsImaging and clinical data were collected from 15 PREDICT-HD sites. This study uses DWI to characterise diffusivity in specific regions of PFC WM defined by FreeSurfer in 53 prodromal HD participants and 34 controls. A streamline-specific alteration was assessed in four major PFC WM tracts: forceps minor (FM), anterior thalamic radiations (ATR), inferior fronto-occipital fasciculi (IFO), uncinate fasciculi (UNC).ResultsStatistically significant increases in mean diffusivity (MD) and radial diffusivity (RD) among CAP groups relative to controls were seen in inferior and lateral PFC regions. White matter alterations in FM, ATR, and IFO showed robust associations with neuropsychological measures of executive functioning.ConclusionsThe gradient of effects that tracked with CAP group suggests DWI may provide markers of disease progression with increasing diffusivity abnormalities in the lateral PFC of prodromal HD individuals. Our tract study also suggests that long-range tracts that are essential for cross-region information that shows early vulnerability in HD and may help to explain cognitive problems in the prodromal stage.FundingNational Institutes for Health, National Institute of Neurological Disorders and Stroke 040068, and CHDI Foundation, Inc.ReferenceMatsui JT, Vaidya JG, Johnson HJ, et al. Diffusion weighted imaging of prefrontal cortex in prodromal huntington's disease. Human Brain Mapping2013; 1-12:doi:10.1002/hbm.22273

Details

Title: Subtitle: E17 Diffusion Weighted Imaging Study Of Prefrontal Cortex White Matter In Prodromal Huntington Disease
Creators: R Kim
J Matsui
D Wassermann
J Vaidya
H Johnson
V Magnotta
J D Long
J A Mills
M Lowe
K Sakaie
S Rao
M Smith
J Paulsen
Resource Type: Journal article
Publication Details: Journal of neurology, neurosurgery and psychiatry, Vol.85(Suppl 1), pp.A42-A42
DOI: 10.1136/jnnp-2014-309032.120
ISSN: 0022-3050
eISSN: 1468-330X
Language: English
Date published: 09/01/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics; University College Courses
Record Identifier: 9984066391602771

Metrics

15 Record Views