Journal article
E3 ubiquitin ligase Cbl-b in innate and adaptive immunity
Cell cycle (Georgetown, Tex.), Vol.13(12), pp.1875-1884
06/15/2014
DOI: 10.4161/cc.29213
PMCID: PMC4111751
PMID: 24875217
Abstract
Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b), a RING finger E3 ubiquitin-protein ligase, has been demonstrated to play a crucial role in establishing the threshold for T-cell activation and controlling peripheral T-cell tolerance via multiple mechanisms. Accumulating evidence suggests that Cbl-b also regulates innate immune responses and plays an important role in host defense to pathogens. Understanding the signaling pathways regulated by Cbl-b in innate and adaptive immune cells is therefore essential for efficient manipulation of Cbl-b in emerging immunotherapies for human disorders such as autoimmune diseases, allergic inflammation, infections, and cancer. In this article, we review the latest developments in the molecular structural basis of Cbl-b function, the regulation of Cbl-b expression, the signaling mechanisms of Cbl-b in immune cells, as well as the biological function of Cbl-b in physiological and pathological immune responses in animal models and human diseases.
Details
- Title: Subtitle
- E3 ubiquitin ligase Cbl-b in innate and adaptive immunity
- Creators
- Qingjun Liu - The Ohio State UniversityHong Zhou - Laboratory of Immunohematology; Beijing Institute of Transfusion Medicine; Beijing, PR ChinaWallace Y Langdon - University of Western AustraliaJian Zhang - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- Cell cycle (Georgetown, Tex.), Vol.13(12), pp.1875-1884
- Publisher
- Landes Bioscience
- DOI
- 10.4161/cc.29213
- PMID
- 24875217
- PMCID
- PMC4111751
- ISSN
- 1538-4101
- eISSN
- 1551-4005
- Language
- English
- Date published
- 06/15/2014
- Academic Unit
- Pathology
- Record Identifier
- 9984195952402771
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