Journal article
E4ORF3 Requirement for Achieving Long-Term Transgene Expression from the Cytomegalovirus Promoter in Adenovirus Vectors
Journal of virology, Vol.73(8), pp.7031-7034
Note
08/1999
DOI: 10.1128/jvi.73.8.7031-7034.1999
PMCID: PMC112791
PMID: 10400804
Abstract
Analysis of transgene expression under the control of the cytomegalovirus (CMV) promoter from adenovirus vectors in which the E4 region was modified indicated that E4ORF3 is required for long-term expression in the murine lung. CMV promoter truncation led to the persistence of expression in the absence of E4, thus eliminating the ORF3 requirement.
Details
- Title: Subtitle
- E4ORF3 Requirement for Achieving Long-Term Transgene Expression from the Cytomegalovirus Promoter in Adenovirus Vectors
- Creators
- Donna Armentano - Genzyme Corporation, Framingham, Massachusetts 01701-9322Michael P Smith - Genzyme Corporation, Framingham, Massachusetts 01701-9322Cathleen C Sookdeo - Genzyme Corporation, Framingham, Massachusetts 01701-9322Joseph Zabner - Genzyme Corporation, Framingham, Massachusetts 01701-9322Michael A Perricone - Genzyme Corporation, Framingham, Massachusetts 01701-9322Judith A St. George - Genzyme Corporation, Framingham, Massachusetts 01701-9322Samuel C Wadsworth - Genzyme Corporation, Framingham, Massachusetts 01701-9322Richard J Gregory - Genzyme Corporation, Framingham, Massachusetts 01701-9322
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.73(8), pp.7031-7034
- Publisher
- American Society for Microbiology
- Series
- Note
- DOI
- 10.1128/jvi.73.8.7031-7034.1999
- PMID
- 10400804
- PMCID
- PMC112791
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Language
- English
- Date published
- 08/1999
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094759002771
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