Journal article
EBV and genomic instability-A new look at the role of the virus in the pathogenesis of Burkitt's lymphoma
Seminars in cancer biology, Vol.19(6), pp.394-400
12/01/2009
DOI: 10.1016/j.semcancer.2009.07.005
PMID: 19619655
Abstract
Epidemiological and molecular evidence links Epstein-Barr virus (EBV) carriage to the pathogenesis of human malignancies of lymphoid and epithelial cell origin but the mechanisms of viral oncogenesis are poorly understood. Burkitt's lymphoma, a tumor occurring in both EBV-positive and -negative forms, provides a convenient model for analysis of the relative contribution of genetic changes and viral products that are expressed in the malignant cells. Here we review recent findings that highlight several mechanisms by which EBV could play an important role in oncogenesis by promoting genomic instability. (C) 2009 Elsevier Ltd. All rights reserved.
Details
- Title: Subtitle
- EBV and genomic instability-A new look at the role of the virus in the pathogenesis of Burkitt's lymphoma
- Creators
- Bettina Gruhne - Karolinska InstitutetSiamak Akbari Kamranvar - Karolinska InstitutetMaria G. Masucci - Karolinska InstitutetRamakrishna Sompallae - Karolinska Institutet
- Resource Type
- Journal article
- Publication Details
- Seminars in cancer biology, Vol.19(6), pp.394-400
- Publisher
- Elsevier
- DOI
- 10.1016/j.semcancer.2009.07.005
- PMID
- 19619655
- ISSN
- 1044-579X
- eISSN
- 1096-3650
- Number of pages
- 7
- Grant note
- Swedish Cancer Society LSHC-CT-2005-018704 / European Community Integrated Project on Infection and Cancer, INCA; Institut National du Cancer (INCA) France Swedish Medical Research Council and Karolinska Institutet, Stockholm, Sweden; Swedish Medical Research Council (SMRC)
- Language
- English
- Date published
- 12/01/2009
- Academic Unit
- Pathology
- Record Identifier
- 9984622751602771
Metrics
7 Record Views