Journal article
EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort
Leukemia & lymphoma, Vol.64(5), pp.1026-1034
2023
DOI: 10.1080/10428194.2023.2191152
PMID: 36960939
Abstract
The objective of this multicenter retrospective study was to examine the incidence, patient characteristics, pathology, and outcomes associated with Epstein-Barr virus (EBV)-related CNS lymphoma (CNSL) in older patients. Among 309 CNSL patients aged ≥60, 11.7% had EBV + tumors of which 72.2% were solid organ transplant (SOT)-related post-transplant lymphoproliferative disorders (PTLD). Younger age, SOT or autoimmune disease, and immunosuppressive treatment correlated highly with EBV-positivity. EBV + tumors were associated with absent C-MYC and BCL6 expression. EBV + PTLD was more likely to be associated with the absence of CD5 expression
.
EBV + non-PTLD had better median OS (not reached) compared to EBV + PTLD (10.8 months) and EBV-negative patients (43 months). Multivariable Cox regression analysis showed that age, performance status, and PTLD were negative predictors of OS. EBV status and immunosuppressive treatment were not correlated with OS. Our findings merit further investigation of EBV + PCNSL tumors and EBV-directed therapies.
Details
- Title: Subtitle
- EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort
- Creators
- Prashasti Agrawal - NewYork–Presbyterian HospitalKevin A. David - Rutgers, The State University of New JerseyZhengming Chen - NewYork–Presbyterian HospitalSuchitra Sundaram - Roswell Park Cancer InstituteSeo-Hyun Kim - Rush University Medical CenterRyan Vaca - Pennsylvania State UniversityYong Lin - Rutgers, The State University of New JerseySamuel Singer - Hackensack University Medical CenterMary-Kate Malecek - Washington University in St. LouisJordan Carter - Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.Adam Zayac - Brown UniversityMyung Sun Kim - Oregon Health & Science UniversityNishitha Reddy - Vanderbilt University Medical CenterDouglas Ney - University of Colorado DenverAlma Habib - University of MinnesotaChristopher Strouse - University of IowaJerome Graber - University of WashingtonVeronika Bachanova - University of MinnesotaSidra Salman - Loyola University ChicagoJean A. Vendiola - Loyola University ChicagoNasheed Hossain - Loyola University ChicagoMazie Tsang - University of California, San FranciscoAjay Major - University of ChicagoMaher K. Gandhi - Princess Alexandra HospitalColm Keane - Princess Alexandra HospitalDavid A. Bond - The Ohio State UniversityMatthew Folstad - University of Wisconsin–MadisonJulie Chang - University of Wisconsin–MadisonAngel Mier-Hicks - Roswell Park Cancer InstitutePallawi Torka - Roswell Park Cancer InstitutePriya Rajakumar - Rush University Medical CenterParameswaran Venugopal - Rush University Medical CenterStephanie Berg - Loyola University ChicagoMichael Glantz - Pennsylvania State UniversitySamuel A. Goldlust - Hackensack University Medical CenterRahul Matnani - Rutgers, The State University of New JerseyPallavi Kumar - Rutgers, The State University of New JerseyThomas A. Ollila - Brown UniversityJohnny Cai - Oregon Health & Science UniversityStephen E. Spurgeon - Oregon Health & Science UniversityAlex G. Sieg - University of IowaJoseph Cleveland - University of California, San FranciscoNarendranath Epperla - The Ohio State UniversityReem Karmali - Northwestern UniversitySeema Naik - Pennsylvania State UniversitySonali M. Smith - University of ChicagoJames L. Rubenstein - University of California, San FranciscoBrad S. Kahl - Washington University in St. LouisAmy Chadburn - NewYork–Presbyterian HospitalAndrew M. Evens - Rutgers, The State University of New JerseyPeter Martin - NewYork–Presbyterian Hospital
- Resource Type
- Journal article
- Publication Details
- Leukemia & lymphoma, Vol.64(5), pp.1026-1034
- Publisher
- Taylor & Francis
- DOI
- 10.1080/10428194.2023.2191152
- PMID
- 36960939
- ISSN
- 1042-8194
- eISSN
- 1029-2403
- Grant note
- name: NIH, award: R01 CA260691
- Language
- English
- Electronic publication date
- 03/24/2023
- Date published
- 2023
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984380369902771
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