Journal article
EFFECTS OF DMDP, A TIAPAMIL ANALOG, ON ADRIAMYCIN EFFLUX IN ADRIAMYCIN-RESISTANT AND ADRIAMYCIN-SENSITIVE P388 CELLS
Anticancer research, Vol.7(6), pp.1105-1108
11/01/1987
PMID: 3442407
Abstract
The calcium channel blockers 'DMDP' [N-3,4-dimethoxyphenethyl)-N-methyl-2-(2-naphthyl-m-dithane-2-prop ylamine)] and verapamil inhibited the active efflux of adriamycin from adriamycin-resistant P388 leukemia cells but had no effect on the drug-sensitive cell line. However, after removal of the calcium channel blockers, DMDP at a low drug concentration caused a much longer inhibition of this efflux pathway than verapamil. This may be attributed to the higher binding affinity of DMDP for receptor sites.
Details
- Title: Subtitle
- EFFECTS OF DMDP, A TIAPAMIL ANALOG, ON ADRIAMYCIN EFFLUX IN ADRIAMYCIN-RESISTANT AND ADRIAMYCIN-SENSITIVE P388 CELLS
- Creators
- S RadelE MayhewY M Rustum
- Resource Type
- Journal article
- Publication Details
- Anticancer research, Vol.7(6), pp.1105-1108
- Publisher
- Int Inst Anticancer Research
- PMID
- 3442407
- ISSN
- 0250-7005
- eISSN
- 1791-7530
- Number of pages
- 4
- Grant note
- CA 37304; CA18420 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01CA037304 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 11/01/1987
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359853802771
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