EIF4A2 as another novel fusion partner of PLAG1 in lipoblastoma

Rofieda R Alwaqfi; Jonathan J Davick; Aaron D Bossler

doi:10.1016/j.hpr.2021.300582

Back

EIF4A2 as another novel fusion partner of PLAG1 in lipoblastoma

Journal article

Open access

EIF4A2 as another novel fusion partner of PLAG1 in lipoblastoma

Rofieda R Alwaqfi, Jonathan J Davick and Aaron D Bossler

Human Pathology Reports, Vol.27, p.300582

03/2022

DOI: 10.1016/j.hpr.2021.300582

Files and links (1)

url

https://doi.org/10.1016/j.hpr.2021.300582View

Published (Version of record) Open Access

Abstract

The 5th edition of the WHO classification of Soft Tissue and Bone tumors recognizes lipoblastoma as a benign adipocytic tumor with excellent prognosis and a recurrence rate of 13–46%. The characteristic genomic alteration that helps separate lipoblastoma from morphologic mimics particularly myxoid liposarcoma is rearrangement of 8q11-13 involving PLAG1. PLAG1 (Pleomorphic adenoma gene 1) is located at 8q12.1 and have been reported to be involved in chromosome rearrangements in various tumors including lipoblastoma, epithelial, and mesenchymal tumors. At least 20 fusion partners of PLAG1 have been reported. This report presents EIF4A2 (Eukaryotic Translation Initiation Factor 4A2) as a novel fusion partner of PLAG1.

EIF4A2

Lipoblastoma

PLAG1

Details

Title: Subtitle: EIF4A2 as another novel fusion partner of PLAG1 in lipoblastoma
Creators: Rofieda R Alwaqfi
Jonathan J Davick
Aaron D Bossler
Resource Type: Journal article
Publication Details: Human Pathology Reports, Vol.27, p.300582
DOI: 10.1016/j.hpr.2021.300582
ISSN: 2772-736X
Publisher: Elsevier Inc
Language: English
Date published: 03/2022
Academic Unit: Pathology
Record Identifier: 9984202245202771

Metrics

33 Record Views