ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing

Sarit Smolikov; Yuval Mazor; Anat Krauskopf

doi:10.1073/pnas.0307796100

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ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing

Journal article

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ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing

Sarit Smolikov, Yuval Mazor and Anat Krauskopf

Proceedings of the National Academy of Sciences - PNAS, Vol.101(6), pp.1656-1661

02/10/2004

DOI: 10.1073/pnas.0307796100

PMCID: PMC341813

PMID: 14745004

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Abstract

Telomeres, the natural ends of eukaryotic chromosomes, prevent the loss of chromosomal sequences and preclude their recognition as broken DNA. Telomere length is kept under strict boundaries by the action of various proteins, some with negative and others with positive effects on telomere length. Recently, data have been accumulating to support a role for DNA replication in the control of telomere length, although through a currently poorly understood mechanism. Elg1p, a replication factor C (RFC)-like protein of yeast, contributes to genome stability through a putative replication-associated function. Here, we show that Elg1p participates in negative control of telomere length and in telomeric silencing through a replication-mediated pathway. We show that the telomeric function of Elg1 is independent of recombination and completely dependent on an active telomerase. Additionally, this function depends on yKu and DNA polymerase. We discuss alternative models to explain how Elg1p affects telomere length.

Carrier Proteins - physiology

Carrier Proteins - genetics

Base Sequence

Gene Silencing

Saccharomyces cerevisiae Proteins

DNA Primers

Telomere

Details

Title: Subtitle: ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing
Creators: Sarit Smolikov - Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel. smolik@post.tau.ac.il
Yuval Mazor
Anat Krauskopf
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.101(6), pp.1656-1661
DOI: 10.1073/pnas.0307796100
PMID: 14745004
PMCID: PMC341813
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: United States
Language: English
Date published: 02/10/2004
Academic Unit: Biology
Record Identifier: 9983992062802771

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