Journal article
ENIGMA-anxietyworking group: Rationale for and organization oflarge-scaleneuroimaging studies of anxiety disorders
Human brain mapping, Vol.43(1), pp.83-112
01/01/2022
DOI: 10.1002/hbm.25100
PMID: 32618421
Abstract
Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA-Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA-Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders.
Details
- Title: Subtitle
- ENIGMA-anxietyworking group: Rationale for and organization oflarge-scaleneuroimaging studies of anxiety disorders
- Creators
- Janna Marie Bas-Hoogendam - Leiden UniversityNynke A. Groenewold - University of Cape TownMoji Aghajani - Amsterdam NeuroscienceGabrielle F. Freitag - National Institute of Mental HealthAnita Harrewijn - National Institute of Mental HealthKevin Hilbert - Humboldt-Universität zu BerlinNeda Jahanshad - University of Southern CaliforniaSophia I. Thomopoulos - University of Southern CaliforniaPaul M. Thompson - University of Southern CaliforniaDick J. Veltman - Amsterdam University Medical CentersAnderson M. Winkler - National Institute of Mental HealthUlrike Lueken - Humboldt-Universität zu BerlinDaniel S. Pine - National Institute of Mental HealthNic J. A. van der Wee - Leiden University Medical CenterDan J. Stein - University of Cape TownENIGMA-Anxiety Working GroupJacqueline Clauss (Contributor) - Psychiatry
- Resource Type
- Journal article
- Publication Details
- Human brain mapping, Vol.43(1), pp.83-112
- DOI
- 10.1002/hbm.25100
- PMID
- 32618421
- NLM abbreviation
- Hum Brain Mapp
- ISSN
- 1065-9471
- eISSN
- 1097-0193
- Publisher
- Wiley
- Number of pages
- 30
- Grant note
- P01AG055367 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) P01 AG026572; P01 AG055367; P41 EB015922; R01 AG060610; R56 AG058854; RF1 AG051710; U54 EB020403 / U.S. National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Anxiety Disorders Research Network European College of Neuropsychopharmacology MH002781 / Intramural Research Training Award (IRTA) program within the National Institute of Mental Health under the Intramural Research Program (NIMH-IRP) T32MH100019; T32MH112485 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) 10-000-1002 / Geestkracht programme of the Netherlands Organization for Health Research and Development (ZonMw) EU7th FrameWork Marie Curie Actions International Staff Exchange Scheme grant 'European and South African Research Network in Anxiety Disorders' (EUSARNAD); Marie Curie Actions P41EB015922 / National Institute of Biomedical Imaging and Bioengineering; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) SA Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 44541416 -TRR 58 / Deutsche Forschungsgemeinschaft (DFG, German Research Foundation); German Research Foundation (DFG)
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Psychiatry
- Record Identifier
- 9985223623802771
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