ENaC Subunits Are Molecular Components of the Arterial Baroreceptor Complex

HEATHER A DRUMMOND; MICHAEL J WELSH; FRANÇOIS M ABBOUD

doi:10.1111/j.1749-6632.2001.tb03665.x

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ENaC Subunits Are Molecular Components of the Arterial Baroreceptor Complex

Journal article

Peer reviewed

ENaC Subunits Are Molecular Components of the Arterial Baroreceptor Complex

HEATHER A DRUMMOND, MICHAEL J WELSH and FRANÇOIS M ABBOUD

Annals of the New York Academy of Sciences, Vol.940(1), pp.42-47

06/2001

DOI: 10.1111/j.1749-6632.2001.tb03665.x

PMID: 11458698

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Abstract

: Mechanosensation is essential to the perception of our environment. It is required for hearing, touch, balance, proprioception, and blood pressure homeostasis. Yet little is known about the identity of ion‐channel complexes that transduce mechanical stimuli into neuronal responses. Genetic studies in Caenorhabditis elegans suggest that members of the DEG/ENaC family may be mechanosensors. Therefore we tested the hypothesis that mammalian epithelial Na+‐channel (ENaC) subunits contribute to the mechanosensor in baroreceptor neurons. The data presented here show that ENaC transcripts and proteins are expressed in mechanosensory neurons and at the putative sites of mechanotransduction in baroreceptor sensory‐nerve terminals. Additionally, known ENaC inhibitors, amiloride and benzamil, disrupt mechanotransduction in arterial baroreceptor neurons. These data are consistent with the hypothesis that DEG/ENaC proteins are components of mechanosensitive ion‐channel complexes.

Mechanosensation

Arterial baroreceptor

Mechanoreception

Epithelial sodium channel

Baroreflex

Merkel‐cell‐neurite complex

Pacinian‐like corpuscle

Blood pressure

Meissner‐like corpuscle

Ion channel

Degenerin

Details

Title: Subtitle: ENaC Subunits Are Molecular Components of the Arterial Baroreceptor Complex
Creators: HEATHER A DRUMMOND
MICHAEL J WELSH
FRANÇOIS M ABBOUD
Resource Type: Journal article
Publication Details: Annals of the New York Academy of Sciences, Vol.940(1), pp.42-47
DOI: 10.1111/j.1749-6632.2001.tb03665.x
PMID: 11458698
NLM abbreviation: Ann N Y Acad Sci
ISSN: 0077-8923
eISSN: 1749-6632
Publisher: Blackwell Publishing Ltd; Oxford, UK
Number of pages: 6
Language: English
Date published: 06/2001
Academic Unit: Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
Record Identifier: 9984025585702771

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