Journal article
ERK Plays a Regulatory Role in Induction of LTP by Theta Frequency Stimulation and Its Modulation by β-Adrenergic Receptors
Neuron (Cambridge, Mass.), Vol.24(3), pp.715-726
1999
DOI: 10.1016/S0896-6273(00)81124-1
PMID: 10595521
Abstract
MAP kinase (ERK) translates cell surface signals into alterations in transcription. We have found that ERK also regulates hippocampal neuronal excitability during 5 Hz stimulation and thereby regulates forms of long-term potentiation (LTP) that do not require macromolecular synthesis. Moreover, ERK-mediated changes in excitability are selectively required for some forms of LTP but not others. ERK is required for the early phase of LTP elicited by brief 5 Hz stimulation, as well as for LTP elicited by more prolonged 5 Hz stimulation when paired with β1-adrenergic receptor activation. By contrast, ERK plays no role in LTP elicited by a single 1 s 100 Hz train. Consistent with these results, we find that ERK is activated by β-adrenergic receptors in CA1 pyramidal cell somas and dendrites.
Details
- Title: Subtitle
- ERK Plays a Regulatory Role in Induction of LTP by Theta Frequency Stimulation and Its Modulation by β-Adrenergic Receptors
- Creators
- Danny G Winder - Columbia UniversityKelsey C Martin - Columbia UniversityIsabel A Muzzio - Columbia UniversityDaniel Rohrer - Stanford UniversityAndrzej Chruscinski - Stanford UniversityBrian Kobilka - Stanford UniversityEric R Kandel - Columbia University
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.24(3), pp.715-726
- DOI
- 10.1016/S0896-6273(00)81124-1
- PMID
- 10595521
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1999
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984294922602771
Metrics
10 Record Views