Journal article
ESR detection of endogenous ascorbate free radical in mouse skin: enhancement of radical production during UV irradiation following application of chlorpromazine
Photochemistry and photobiology, Vol.46(2), pp.161-164
08/1987
DOI: 10.1111/j.1751-1097.1987.tb04751.x
PMID: 2819904
Abstract
Using electron spin resonance spectroscopy, we observed that UV radiation (330 nm) increased the endogenous ascorbate free radical concentration in hairless mouse (HRS/J) skin. When the skin was topically treated with a chlorpromazine solution prior to illumination, UV irradiation caused the ascorbate free radical concentration to increase even more. This observation suggests that there is an increased UV-induced oxidative stress in the presence of chlorpromazine, probably caused by the production of free radicals from chlorpromazine.
Details
- Title: Subtitle
- ESR detection of endogenous ascorbate free radical in mouse skin: enhancement of radical production during UV irradiation following application of chlorpromazine
- Creators
- G R BuettnerA G MottenR D HallC F Chignell
- Resource Type
- Journal article
- Publication Details
- Photochemistry and photobiology, Vol.46(2), pp.161-164
- Publisher
- United States
- DOI
- 10.1111/j.1751-1097.1987.tb04751.x
- PMID
- 2819904
- ISSN
- 0031-8655
- eISSN
- 1751-1097
- Language
- English
- Date published
- 08/1987
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047737902771
Metrics
17 Record Views