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EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea
Journal article   Peer reviewed

EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea

Juan J Sanchez-Ramirez, Matthew R Hoffman, John C Keech, Anthony N Snow, Andrew M Bellizzi and Anand Rajan
Head & neck pathology (Totowa, N.J.), Vol.19(1), 7
01/07/2025
DOI: 10.1007/s12105-024-01746-y
PMCID: PMC11707210
PMID: 39775186

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Abstract

We describe the novel occurrence of a adenocarcinoma involving the trachea, with distinct solid and glandular components, in a 34-year-old patient. We illustrate its morphological and immunophenotypic features and describe the molecular finding of an EWSR1::BEND2 gene fusion detected by next-generation sequencing (NGS). We discuss the findings in comparison to BEND2-fusion associated neoplasms reported in the head and neck region in the literature to date.
Adenocarcinoma - genetics Adenocarcinoma - pathology Adult Biomarkers, Tumor - genetics Humans Male Oncogene Proteins, Fusion - genetics RNA-Binding Protein EWS - genetics Tracheal Neoplasms - genetics Tracheal Neoplasms - pathology

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