EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea

Juan J Sanchez-Ramirez; Matthew R Hoffman; John C Keech; Anthony N Snow; Andrew M Bellizzi; Anand Rajan

doi:10.1007/s12105-024-01746-y

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EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea

Journal article

Peer reviewed

EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea

Juan J Sanchez-Ramirez, Matthew R Hoffman, John C Keech, Anthony N Snow, Andrew M Bellizzi and Anand Rajan

Head & neck pathology (Totowa, N.J.), Vol.19(1), 7

01/07/2025

DOI: 10.1007/s12105-024-01746-y

PMCID: PMC11707210

PMID: 39775186

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https://pmc.ncbi.nlm.nih.gov/articles/PMC11707210/pdf/12105_2024_Article_1746.pdfView

Open Access

Abstract

We describe the novel occurrence of a adenocarcinoma involving the trachea, with distinct solid and glandular components, in a 34-year-old patient. We illustrate its morphological and immunophenotypic features and describe the molecular finding of an EWSR1::BEND2 gene fusion detected by next-generation sequencing (NGS). We discuss the findings in comparison to BEND2-fusion associated neoplasms reported in the head and neck region in the literature to date.

Adenocarcinoma - genetics

Adenocarcinoma - pathology

Adult

Biomarkers, Tumor - genetics

Humans

Male

Oncogene Proteins, Fusion - genetics

RNA-Binding Protein EWS - genetics

Tracheal Neoplasms - genetics

Tracheal Neoplasms - pathology

Details

Title: Subtitle: EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea
Creators: Juan J Sanchez-Ramirez - University of Iowa Hospitals and Clinics
Matthew R Hoffman - University of Iowa
John C Keech - University of Iowa
Anthony N Snow - University of Iowa
Andrew M Bellizzi - University of Iowa
Anand Rajan - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Head & neck pathology (Totowa, N.J.), Vol.19(1), 7
DOI: 10.1007/s12105-024-01746-y
PMID: 39775186
PMCID: PMC11707210
NLM abbreviation: Head Neck Pathol
ISSN: 1936-0568
eISSN: 1936-0568
Publisher: SPRINGER
Language: English
Date published: 01/07/2025
Academic Unit: Communication Sciences and Disorders; Stead Family Department of Pediatrics; Pathology; Cardiothoracic Surgery; Otolaryngology
Record Identifier: 9984771633402771

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