Journal article
EXERCISE PREVENTS DEVELOPMENT OF AUTONOMIC DYSREGULATION AND HYPERALGESIA IN A MOUSE MODEL OF CHRONIC MUSCLE PAIN
Pain (Amsterdam), Vol.157(2), pp.387-398
02/2016
DOI: 10.1097/j.pain.0000000000000330
PMCID: PMC4724275
PMID: 26313406
Abstract
Chronic musculoskeletal pain (CMP) conditions, like fibromyalgia, are associated with widespread pain and alterations in autonomic function. Regular physical activity prevents development of CMP and can reduce autonomic dysfunction. We tested if there were alterations in autonomic function in sedentary mice with CMP, and if exercise reduced the autonomic dysfunction and pain induced by CMP. CMP was induced by two intramuscular injections of pH 5 in combination with a single fatiguing exercise task. A running wheel was placed into cages so that the mouse had free access for either 5 days or 8 weeks (exercise groups) and these animals were compared to sedentary mice without running wheels. Autonomic function and nociceptive withdrawal thresholds of the paw and muscle were assessed before and after induction of CMP in exercised and sedentary mice. In sedentary mice, we show decreased baroreflex sensitivity, increased blood pressure variability, decreased heart rate variability and decreased withdrawal thresholds of the paw and muscle 24h after induction of CMP. There were no sex differences after induction of the CMP in any outcome measure. We further show that both 5 days and 8 weeks of physical activity prevent the development of autonomic dysfunction and decreases in withdrawal threshold induced by CMP. Thus, this study uniquely shows development of autonomic dysfunction in animals with chronic muscle hyperalgesia that can be prevented with as little as 5 days of physical activity, and suggest that physical activity may prevent the development of pain and autonomic dysfunction in people with CMP.
Details
- Title: Subtitle
- EXERCISE PREVENTS DEVELOPMENT OF AUTONOMIC DYSREGULATION AND HYPERALGESIA IN A MOUSE MODEL OF CHRONIC MUSCLE PAIN
- Creators
- Rasna Sabharwal - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242Lynn Rasmussen - Department of Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, IA 52242Kathleen A Sluka - Department of Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, IA 52242Mark W Chapleau - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.157(2), pp.387-398
- DOI
- 10.1097/j.pain.0000000000000330
- PMID
- 26313406
- PMCID
- PMC4724275
- NLM abbreviation
- Pain
- ISSN
- 0304-3959
- eISSN
- 1872-6623
- Language
- English
- Date published
- 02/2016
- Academic Unit
- Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Cardiovascular Medicine; Nursing; Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025344302771
Metrics
25 Record Views