EXERCISE TRAINING IMPROVES ENDOTHELIAL FUNCTION IN RESISTANCE ARTERIES OF YOUNG PREHYPERTENSIVES

Darren T Beck; Jeffrey S Martin; Darren P Casey; Randy W Braith

doi:10.1038/jhh.2013.109

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EXERCISE TRAINING IMPROVES ENDOTHELIAL FUNCTION IN RESISTANCE ARTERIES OF YOUNG PREHYPERTENSIVES

Journal article

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EXERCISE TRAINING IMPROVES ENDOTHELIAL FUNCTION IN RESISTANCE ARTERIES OF YOUNG PREHYPERTENSIVES

Darren T Beck, Jeffrey S Martin, Darren P Casey and Randy W Braith

Journal of human hypertension, Vol.28(5), pp.303-309

05/2014

DOI: 10.1038/jhh.2013.109

PMCID: PMC4159938

PMID: 24172292

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http://doi.org/10.1038/jhh.2013.109View

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Abstract

Prehypertension is associated with reduced conduit artery endothelial function and perturbation of oxidant/antioxidant status. It is unknown if endothelial dysfunction persists to resistance arteries and if exercise training effects oxidant/antioxidant balance in young prehypertensives. We examined resistance artery function using venous occlusion plethysmography measurement of forearm (FBF) and calf blood flow (CBF) at rest and during reactive hyperemia, as well as lipid peroxidation (8-iso-PGF 2α ) and antioxidant capacity (Trolox-equivalent antioxidant capacity; TEAC) before and after exercise intervention or time-control. Forty-three unmedicated prehypertensive and fifteen matched normotensive time-controls met screening requirements and participated in the study (age: 21.1±0.8 years). Prehypertensive subjects were randomly assigned to resistance exercise training (PHRT; n=15), endurance exercise training (PHET; n=13) or time-control groups (PHTC; n=15). Treatment groups exercised 3 days per week for 8 weeks. Peak and total FBF were lower in prehypertensives than normotensives (12.7±1.2 ml/min/100ml tissue and 89.1±7.7 ml/min/100ml tissue vs. 16.3±1.0 ml/min/100ml tissue and 123.3±6.4 ml/min/100ml tissue, respectively; p<0.05). Peak and total CBF were lower in prehypertensives than normotensives (15.3±1.2 ml/min/100ml tissue and 74±8.3 ml/min/100ml tissue vs. 20.9±1.4 ml/min/100ml tissue and 107±9.2 ml/min/100ml tissue, respectively; p<0.05). PHRT and PHET improved humoral measures of Trolox-equivalent antioxidant-capacity (TEAC) (+24% and +30%) and 8-iso-PGF 2α (−43% and −40%, respectively; p<0.05). This study provides evidence that young prehypertensives exhibit reduced resistance artery endothelial function and that short term (8weeks) resistance or endurance training are effective in improving resistance artery endothelial function and oxidant/antioxidant balance in young prehypertensives.

endothelial function

exercise

oxidants

resistance arteries

antioxidants

prehypertension

Details

Title: Subtitle: EXERCISE TRAINING IMPROVES ENDOTHELIAL FUNCTION IN RESISTANCE ARTERIES OF YOUNG PREHYPERTENSIVES
Creators: Darren T Beck - Department of Kinesiology, University of Rhode Island, Kingston, RI 02881
Jeffrey S Martin - Department of Biomedical Sciences, Quinnipiac University, Hamden, CT 06518
Darren P Casey - Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA 52242
Randy W Braith - Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611
Resource Type: Journal article
Publication Details: Journal of human hypertension, Vol.28(5), pp.303-309
DOI: 10.1038/jhh.2013.109
PMID: 24172292
PMCID: PMC4159938
NLM abbreviation: J Hum Hypertens
ISSN: 0950-9240
eISSN: 1476-5527
Language: English
Date published: 05/2014
Academic Unit: Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984046804802771

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