Journal article
Early Airway Structural Changes in Cystic Fibrosis Pigs as a Determinant of Particle Distribution and Deposition
Annals of biomedical engineering, Vol.42(4), pp.915-927
04/2014
DOI: 10.1007/s10439-013-0955-7
PMCID: PMC3954455
PMID: 24310865
Abstract
The pathogenesis of cystic fibrosis (CF) airway disease is not well understood. A porcine CF model was recently generated, and these animals develop lung disease similar to humans with CF. At birth, before infection and inflammation, CF pigs have airways that are irregularly shaped and have a reduced caliber compared to non-CF pigs. We hypothesized that these airway structural abnormalities affect airflow patterns and particle distribution. To test this hypothesis we used computational fluid dynamics (CFD) on airway geometries obtained by computed tomography of newborn non-CF and CF pigs. For the same flow rate, newborn CF pig airways exhibited higher air velocity and resistance compared to non-CF. Moreover we found that, at the carina bifurcation, particles greater than 5-µm preferably distributed to the right CF lung despite almost equal airflow ventilation in non-CF and CF. CFD modeling also predicted that deposition efficiency was greater in CF compared to non-CF for 5- and 10-µm particles. These differences were most significant in the airways included in the geometry supplying the right caudal, right accessory, left caudal, and left cranial lobes. The irregular particle distribution and increased deposition in newborn CF pig airways suggest that early airway structural abnormalities might contribute to CF disease pathogenesis.
Details
- Title: Subtitle
- Early Airway Structural Changes in Cystic Fibrosis Pigs as a Determinant of Particle Distribution and Deposition
- Creators
- Maged Awadalla - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, 52242Shinjiro Miyawaki - Department of Civil and Environmental Engineering, University of Iowa, Iowa City, IA, 52242Mahmoud H. Abou Alaiwa - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, 52242Ryan J Adam - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, 52242Drake C Bouzek - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, 52242Andrew S Michalski - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, 52242Matthew K Fuld - Department of Radiology, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, 52242Karen J Reynolds - Medical Device Research Institute, School of Computer Science, Engineering, and Mathematics, Flinders University, Adelaide, Australia, 5001Eric A Hoffman - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, 52242Ching-Long Lin - Department of Mechanical and Industrial Engineering, University of Iowa, Iowa City, IA, 52242David A Stoltz - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, 52242
- Resource Type
- Journal article
- Publication Details
- Annals of biomedical engineering, Vol.42(4), pp.915-927
- DOI
- 10.1007/s10439-013-0955-7
- PMID
- 24310865
- PMCID
- PMC3954455
- NLM abbreviation
- Ann Biomed Eng
- ISSN
- 0090-6964
- eISSN
- 1573-9686
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Stead Family Department of Pediatrics; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984025404402771
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